Evidence map›Paper›PMID 41642438›Full record

ArticleDiscover oncology2026

Log odds of positive lymph nodes predict surgical prognosis in intrahepatic cholangiocarcinoma based on SEER cohort and nomogram model.

Shan Li, Guoxia Jia, Fan Luo, Jiaxin Yin, Shaochong Deng, Jianfu Zhao, Huizhong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shan Li *Research Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China.
Guoxia Jia *Research Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China.
Fan LuoResearch Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China.
Jiaxin YinResearch Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China.
Shaochong DengDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, China.
Jianfu ZhaoResearch Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China. zhaojianfu@jnu.edu.cn.
Huizhong WangResearch Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Guangzhou, 510630, China. w.hz168@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrahepatic cholangiocarcinoma (ICC) has a high postoperative recurrence rate, but quantitative assessment of lymph node metastasis (LNM) by AJCC staging remains inadequate. The log odds of positive lymph nodes (LODDS) have prognostic value in digestive system tumors, but its application in ICC has yet to be studied.

methodBased on the SEER database (2010–2017), 593 ICC patients after hepatectomy or choledochotomy surgery, Cox regression was applied to analyze the association between LODDS and the risk of all-cause mortality (ACM) and cancer-specific mortality (CSM), and risk thresholds were determined by restricted cubic spline (RCS), and a nomogram predictive model was constructed based on variables screened by Boruta’s algorithm. Patients were stratified by optimal nomogram cutoff, and survival was compared via Kaplan-Meier curves.

resultsLODDS was positively linear correlated with ACM (HR = 2.062, 95% CI: 1.683, 2.527, P < 0.001) and CSM (HR = 2.068, 95% CI: 1.632, 2.622, P < 0.001), with the optimal cutoff value of -0.63. The risk of death was increased 1.7 times in the high LODDS group (>− 0.477) compared with the baseline group. The nomogram integrating variables such as LODDS, T-staging, and tumor size had a C-index of 0.711, which had a good predictive performance. Survival differences were statistically significant for both LODDS-based stratification and nomogram-based risk groups.

conclusionLODDS is an independent prognostic factor for post-operative ICC survival, enabling optimized risk stratification and personalized follow-up strategies.

Indexed as

Clinical predictive modelIntrahepatic cholangiocarcinomaLog odds of positive lymph nodes (LODDS)NomogramSEER database

Identifiers

PMID41642438
PMCPMC12876526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.