ArticleDiscover oncology2026
Circ_0041150 inhibits proliferation of pancreatic adenocarcinoma cells by regulating triglyceride accumulation via the miR-1178-3p/AADAC axis.
Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTriglyceride (TG) metabolism and circular RNAs (circRNAs) are implicated in pancreatic adenocarcinoma (PAAD), but their interconnections remain unclear. This study aims to elucidate the role of hsa_circ_0041150 (circ_0041150) in metabolic mechanism and PAAD progression.
methodsRNA/protein levels were detected by qRT-PCR/Western blot. Cell proliferation was evaluated using CCK-8 and EdU assays. TG accumulation was assessed via BODIPY 493/503 staining and a commercial TG assay kit. Interactions among circ_0041150, miR-1178-3p, and AADAC mRNA were analyzed via bioinformatics tools, RNA pull-down, dual-luciferase reporter, and RNA immunoprecipitation (RIP) assays.
resultscirc_0041150 was downregulated in PAAD tissues and cell lines, and its expression correlated with key clinicopathological features of PAAD. Mechanistically, circ_0041150 acts as a competing endogenous RNA (ceRNA) to sponge miR-1178-3p, thereby upregulating AADAC expression, and inhibiting TG accumulation and PAAD cell proliferation. Knockdown of circ_0041150 promoted proliferation and TG accumulation, and these effects were partially reversed by miR-1178-3p inhibition or AADAC overexpression.
conclusioncirc_0041150 regulates AADAC by sponging miR-1178-3p, inhibiting PAAD progression and TG accumulation, and providing diagnostic and therapeutic targets via the circ_0041150/miR-1178-3p/AADAC axis.
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