Evidence map›Paper›PMID 41642407›Full record

ReviewCurrent pain and headache reports2026

Perioperative Management of Patients on Buprenorphine.

Nalini Vadivelu, Nicholas Mydlo, Christopher Dextras, Jessica Ng, Matthew Silverman, Gopal Kodumudi, Sean Chowdhari, Roberta Hines, Donna-Ann Thomas, Thomas Hickey

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nalini VadiveluYale University, New Haven, USA. Nalini.Vadivelu@yale.edu.
Nicholas MydloUniversity of Virginia Post Baccalaureate Pre-Medical Program, Charlottesville, USA.
Christopher DextrasYale University, New Haven, USA.
Jessica NgYale University, New Haven, USA.
Matthew SilvermanYale University, New Haven, USA.
Gopal KodumudiUC Irvine Health, Orange, USA.
Sean ChowdhariYale University, New Haven, USA.
Roberta HinesYale University, New Haven, USA.
Donna-Ann ThomasYale University, New Haven, USA.
Thomas HickeyYale University, New Haven, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of the reviewOur review discusses the pharmacologic profile of buprenorphine, then dives into the current literature regarding buprenorphine's use to treat chronic pain, opioid use disorder, and acute postoperative pain. We aim to focus on how that literature may influence the perioperative management of patients on buprenorphine and prompt reconsideration of buprenorphine as a frontline opioid analgesic. RECENT

findingsBuprenorphine has been used effectively for both acute and chronic pain management, for the treatment of opioid withdrawal, and for the treatment of opioid use disorder due to its unique pharmacological profile. Historically, there has been controversy over the best practice recommendations for buprenorphine use in the perioperative setting, though the data now overwhelmingly refutes the full discontinuation of buprenorphine preoperatively. It has also been seen in recent times that buprenorphine is at least as effective as usual care opioids for acute pain management, with important safety advantages. Expanding our analgesic toolkit to more thoroughly understand the unique mechanism of action and properties of buprenorphine is paramount in our treatment of perioperative pain in both opioid-naïve and opioid-tolerant patients.

Indexed as

Analgesics, OpioidBuprenorphineChronic PainOpioid-Related DisordersPain ManagementPerioperative CarePostoperative PainHumansOpiate Substitution TreatmentAnalgesics, OpioidBuprenorphineAcute post operative painBuprenorphineChronic painOpioid use disorderOpioid withdrwal

Identifiers

PMID41642407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.