Evidence map›Paper›PMID 41642358›Full record

ArticleCurrent microbiology2026

Epidemiological and Genomic Insights into Linezolid-Non-Susceptible Enterococci in Pediatric Patients.

Chao Fang, Zheng Zhou, Xiucai Zhang, Jintao Xia, Shixing Liu, Jianping Li, Mingming Zhou

Abstract read
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In one paragraph

Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Chao FangDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Zheng ZhouDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Xiucai ZhangDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Jintao XiaDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Shixing LiuDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Jianping LiDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Mingming ZhouDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China. 6510053@zju.edu.cn.

Funding

Key Program of The Independent Design Project of National Clinical Research Center for Child Health No. I23J0006"Pioneer" and "Leading Goose" R&D Program of Zhejiang Province 2023C03028Zhejiang Provincial Natural Science Foundation of China No. LTGC23H200006
6 · The paper itself

Abstract

Enterococci are major opportunistic pathogens causing healthcare-associated infections in children. Linezolid, a WHO-designated critically important antibiotic for multidrug-resistant Gram-positive infections, is increasingly challenged by linezolid-non-susceptible enterococci (LNSE). Yet pediatric LNSE epidemiology and genomics data remain scarce, hindering targeted control. We analyzed 26 LNSE strains isolated from Children's Hospital, Zhejiang University School of Medicine (June 2020-July 2024) using MALDI-TOF MS, Vitek2 Compact, micro-broth dilution (for linezolid MIC), MLST, resistance/virulence gene detection, and pan-genome analysis (COG/KEGG annotation). Enterococcus faecalis (E. faecalis) dominated (23/26,88.5%) with ST16 as the major sequence type (ST) and four novel STs identified; all strains harbored optrA and fexA, with species-specific resistance/virulence gene profiles. The 23 E. faecalis strains exhibited an open pan-genome (b = 0.174725), indicating the possible existence of active horizontal gene transfer (HGT), with core, accessory, and unique genes showing distinct functional differentiation. These findings provide critical and robust empirical data to inform the development of targeted prevention and control strategies against LNSE in pediatric populations.

Indexed as

Anti-Bacterial AgentsEnterococcusGram-Positive Bacterial InfectionsLinezolidChildChild, PreschoolChinaDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEnterococcus faecalisGene Transfer, HorizontalGenome, BacterialGenomicsHumansInfantMicrobial Sensitivity TestsAnti-Bacterial AgentsLinezolidVirulence Factors

Identifiers

PMID41642358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.