Evidence map›Paper›PMID 41642328›Full record

ArticleIntensive care medicine2026

Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study.

Gregory L Hundemer, Asnake Y Dumicho, Greg A Knoll, Ron Wald, Samuel A Silver, Oleksa G Rewa, Shannon M Fernando, Margaret Herridge, Ann Bugeja, Manish M Sood and 4 more

Abstract read
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Article in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gregory L HundemerDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Asnake Y DumichoICES uOttawa, Ottawa Hospital Research Institute, Ottawa, Canada.
Greg A KnollDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Ron WaldDivision of Nephrology, Department of Medicine, St. Michael's Hospital, Toronto, Canada.
Samuel A SilverDivision of Nephrology, Department of Medicine, Queen's University, Kingston, Canada.
Oleksa G RewaDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Canada.
Shannon M FernandoDepartment of Critical Care, Lakeridge Health, Oshawa, Canada.
Margaret HerridgeInterdepartmental Division of Critical Care, University Health Network and University of Toronto, Toronto, Canada.
Ann BugejaDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Manish M SoodDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Luana L T N PortoDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Deena FremontDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.
Tim RamsayInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.
Edward G ClarkDivision of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada. edclark@toh.ca.ORCID 0000-0002-6767-1197

Funding

CIHR 143239
6 · The paper itself

Abstract

purposeThe presence and severity of acute kidney injury (AKI) upon ICU admission provides important short- and long-term prognostic information. Existing reports have been limited by inadequate baseline kidney function assessment, incomplete outcome capture, limited adjustment for illness severity, and small sample sizes.

methodsWe conducted a population-level study of all adult (≥ 18 years) Ontario, Canada residents with available outpatient baseline creatinine measurements admitted to the ICU from 2009-2021. AKI at the time of ICU admission was determined according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Outcomes included death and kidney replacement therapy (KRT). Multivariable logistic regression modeling was used to estimate adjusted odds ratios (aOR).

resultsThe study cohort included 484,956 adults (43% female) admitted to the ICU. Mean (SD) age and baseline eGFR were 68 (15) years and 77 (25) mL/min/1.73 m

conclusionThe presence and severity of AKI at the time of ICU admission are strongly associated with adverse health outcomes. Stage 2 and 3 AKI portend a similarly high risk of mortality.

Indexed as

Acute Kidney InjuryIntensive Care UnitsSeverity of Illness IndexAgedCohort StudiesFemaleHumansLogistic ModelsMaleMiddle AgedOntarioAcute kidney injuryAKIEnd-stage kidney diseaseESKDICUIntensive care unitKidneyMortalityRenal

Identifiers

PMID41642328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.