Evidence map›Paper›PMID 41641993›Full record

ArticlemBio2026

Substrate specificity and action mechanism of the HerA-NurA nuclease from the hyperthermophilic archaeon

Keishiro Uda, Takeshi Yamagami, Sonoko Ishino, Christoph Gerle, Chai C Gopalasingam, Hideki Shigematsu, Tomoyuki Numata, Yoshizumi Ishino

Abstract read
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In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keishiro UdaDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.ORCID 0009-0001-0719-3381
Takeshi YamagamiDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-0269-8062
Sonoko IshinoDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-1833-1735
Christoph GerleLife Science Research Infrastructure Group, RIKEN SPring-8 Center, Hyogo, Japan.ORCID 0000-0002-7265-2804
Chai C GopalasingamLife Science Research Infrastructure Group, RIKEN SPring-8 Center, Hyogo, Japan.ORCID 0000-0002-9014-9380
Hideki ShigematsuDiffraction and Scattering Division, Japan Synchrotron Radiation Research Institute, SPring-8, Hyogo, Japan.ORCID 0000-0003-3951-8651
Tomoyuki NumataDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-4244-8829
Yoshizumi IshinoDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-9419-0826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HerA-NurA complex reportedly functions in DNA end resection in archaea. End resection is important to start homologous recombination by forming a single-stranded DNA region with an overhanging 3'-end, which invades double-stranded DNA (dsDNA) with a homologous sequence to form a D-loop. Here, we studied the structure and functions of HerA-NurA from the hyperthermophilic archaeon, IMPORTANCE: To understand the specific function of the HerA-NurA complex, which is believed to function in the end resection process to create a 3'-overhanging DNA for the following strand invasion in homologous recombination, we performed biochemical and structural analyses of this complex from a hyperthermophilic archaeon,

Indexed as

Archaeal ProteinsDeoxyribonucleasesThermococcusDNADNA, ArchaealModels, MolecularProtein ConformationSubstrate SpecificityArchaeal ProteinsDeoxyribonucleasesDNADNA, ArchaealarchaeaDNA repairEM structureend resectionnucleasetranslocase

Identifiers

PMID41641993
PMCPMC12977600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.