Evidence map›Paper›PMID 41641992›Full record

ArticleMicrobiology spectrum2026

Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice.

Samuel Speaks, Jonathan Papa, Matthew McFadden, Jack E Roettger, Benjamin D Liu, Shreenath Mohan, Brendan M Reznik, Steve Leumi, Jana M Cable, Adriana Forero and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Samuel Speaks *Department of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0003-7610-1502
Jonathan Papa *Department of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Matthew McFaddenDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jack E RoettgerDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Benjamin D LiuDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Shreenath MohanDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Brendan M ReznikDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Steve LeumiDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jana M CableDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Adriana ForeroDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-2698-658X
Jacob S YountDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-6128-4575

Funding

Identification of novel type III IFN regulatory pathwaysR35GM150806 · NIGMS · OHIO STATE UNIVERSITY · PI Adriana Forero · 2023 to 2026
$1.6M
American Heart Association Predoc FellowshipBurroughs Wellcome Fund PATHNational Institute of Allergy and Infectious Diseases AI130110National Institute of Allergy and Infectious Diseases AI165391NHLBI NIH HHS HL157215NHLBI NIH HHS HL168501NIGMS NIH HHS GM150806NIGMS NIH HHS R35 GM150806
6 · The paper itself

Abstract

Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in regulating influenza virus infection outcomes. We found that IMPORTANCE: Influenza virus infection activates multiple cell death pathways that shape disease outcomes. Here, we demonstrate that gasdermin E (GSDME)-mediated pyroptotic cell death does not significantly affect lung pathology or survival during severe H1N1 influenza virus infection. This finding contrasts with prior reports showing that GSDME worsens disease caused by H3N2 or H7N9 strains, as well as studies implicating gasdermin D in exacerbating H1N1 pathology. Thus, our data clarify that gasdermin family members contribute to influenza pathogenesis in a context-specific manner, underscoring the importance of considering viral diversity when evaluating the therapeutic potential of targeting cell death pathways.

Indexed as

Influenza A Virus, H1N1 SubtypeOrthomyxoviridae InfectionsReceptors, EstrogenAnimalsDisease Models, AnimalFemaleGasderminsHumansLungMiceMice, Inbred C57BLMice, KnockoutPyroptosisGasderminsGsdme protein, mouseReceptors, Estrogengasdermin Einfluenza viruspyroptosis

Identifiers

PMID41641992
PMCPMC12955486

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.