ArticleJACC. Case reports2026
Scientific and Technical Considerations of the World's First Beating Heart Transplantation in a Human: An Operator's View.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart transplantation remains limited by donor shortage and ischemia-reperfusion injury. While normothermic machine perfusion reduces cold ischemia, maintaining continuous perfusion during implantation remains challenging. CASE SUMMARY: A 67-year-old man with end-stage nonischemic cardiomyopathy underwent the world's first clinical ischemia-free beating heart transplantation using a customized perfusion system that maintained continuous coronary perfusion and electromechanical activity from donor explantation to recipient implantation. The procedure was technically successful, with excellent graft function, although the patient experienced transient metabolic complications postoperatively. DISCUSSION: This case demonstrates that beating heart transplantation is technically feasible and eliminates ischemia-reperfusion injury, a fundamental limitation of conventional transplantation and existing perfusion technologies. The procedure represents a paradigm shift from organ preservation to organ sustainment, offering new possibilities for marginal donor use. TAKE-HOME MESSAGES: Ischemia-free beating heart transplantation is feasible and may redefine graft preservation in cardiac transplantation. Future integration with blood purification technologies and portable perfusion systems could enable long-distance organ transport and expand the donor pool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.