[Design of ZIF-L-based boronate affinity molecularly imprinted material and its application in the detection of ribavirin in environmental water].

Ribavirin （RBV） is a broad-spectrum antiviral drug. It is widely used to treat various viral infections. However， its entry into water bodies can cause serious harm to both the ecological environment and human health. Thus， there is an urgent need for a simple and efficient method to detect RBV for detection purposes. In this study， a two-dimensional ZIF material （ZIF-L） served as the matrix， RBV as the template molecule， and 3-aminophenylboronic acid （APBA） as the functional monomer， using its self-polymerization ability to form a molecularly imprinted layer on the surface of ZIF-L. Imprinted cavities were created using a MeOH-HAc （1∶1， volume ratio） eluent to disrupt the interaction between RBV and APBA， yielding ZIF-L-based boronate affinity molecularly imprinted polymers （ZIF@B-MIPs）. Non-imprinted materials （ZIF@B-NIPs） were prepared identically without RBV. ZIF@B-MIPs features dynamic recognition sites formed through pH-responsive boronate ester bonds. This enabled synergistic recognition based on the template molecule's "shape memory" and "chemical bonding". Scanning electron microscopy （SEM） and Fourier-transform infrared spectroscopy （FT-IR） were employed to characterize the morphology and functional groups of the material. Notably， new FT-IR peaks emerged for ZIF@B-MIPs at 1 381 cm