Evidence map›Paper›PMID 41641467›Full record

ArticleBiomacromolecules2026

Protein-Polysaccharide Bilayer Films: Influence of Protein and Cross-Linker on Interfacial and Functional Properties.

Giuliana T Franco, Luana Figueiredo, Caio G Otoni, Luiz H C Mattoso

Abstract read
In one paragraph

Article in Biomacromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giuliana T FrancoNanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentation - Rua XV de Novembro, 1452, São Carlos, SP 13561-206, Brazil.ORCID 0000-0001-6742-4658
Luana FigueiredoNanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentation - Rua XV de Novembro, 1452, São Carlos, SP 13561-206, Brazil.
Caio G OtoniGraduate Program in Materials Science and Engineering (PPGCEM), Federal University of São Carlos - Rod. Washington Luís, km 235, São Carlos, SP 13565-905, Brazil.ORCID 0000-0001-6734-7381
Luiz H C MattosoNanotechnology National Laboratory for Agriculture (LNNA), Embrapa Instrumentation - Rua XV de Novembro, 1452, São Carlos, SP 13561-206, Brazil.ORCID 0000-0001-7586-1014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-supporting bilayer films were produced by combining a protein (casein or gelatin) and a polysaccharide (carboxymethylcellulose, CMC). Effective interfacial interactions, achieved either physically (primarily via electrostatic interactions) or chemically (with citric acid and 1,2,3,4-butanetetracarboxylic acid (BTCA) as cross-linkers), granted improved mechanical and functional performance. Gelatin layers exhibited strong adhesion across different pH values (3, 4.5, and 8), indicating a minimal role of electrostatic forces in interlayer interactions. In contrast, casein required the incorporation of tannic acid (TA) into the CMC layer as a compatibilizing agent to achieve effective adhesion. Polysaccharide cross-linkers were evaluated in casein-CMC bilayers, where citric acid reduced the water absorption, while BTCA improved water vapor barrier properties but decreased mechanical resistance. Understanding interfacial interactions enables the design of biobased materials with tailored properties, boosting competitiveness and functionality within the circular bioeconomy.

Indexed as

Carboxymethylcellulose SodiumCaseinsCross-Linking ReagentsFood PackagingGelatinButanesCarboxylic AcidsCitric AcidHydrogen-Ion ConcentrationPolyphenolsStatic Electricity1,2,3,4-butanetetracarboxylic acidButanesCarboxylic AcidsCarboxymethylcellulose SodiumCaseinsCitric AcidCross-Linking ReagentsGelatinPolyphenolstannic acid

Identifiers

PMID41641467
PMCPMC12977049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.