ReviewJournal of diabetes and metabolic disorders2026
Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
Review in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Amylin-based obesity therapy: a meta-analysis of Cagrilintide and CagriSema versus placebo.Annals of medicine and surgery (2012) · 2026Article
- Evaluating the therapeutic benefits and safety of ecnoglutide for type 2 diabetes: evidence from a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2026Review
- Evaluating Large Language Models for Food Supplement Development: A Case Study in Glycemic Control.Nutrients · 2026Article
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Authors and funding
17 authors.
Funding
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Abstract
Background: Prediabetes is a high-risk metabolic state associated with progression to type 2 diabetes and increased cardiometabolic burden. Magnesium plays an essential role in insulin signaling and glucose metabolism, with deficiency linked to insulin resistance. However, evidence on oral magnesium supplementation in prediabetes remains limited. Objective: To evaluate the impact of oral magnesium supplementation on glycemic regulation, insulin sensitivity, and cardiometabolic outcomes in adults with prediabetes. Methods: A systematic review and meta-analysis following PRISMA guidelines included randomized controlled trials comparing oral magnesium supplementation to placebo in prediabetic adults. The primary outcome was fasting plasma glucose (FPG). Secondary outcomes included 2-hour OGTT glucose, HbA1c, fasting insulin, HOMA-IR, blood pressure, BMI, waist circumference, lipid parameters, high-sensitivity C-reactive protein, and serum magnesium. Random-effects models were used with subgroup analyses for magnesium chloride (MgCl₂) and magnesium oxide (MgO). Results: Five trials ( Conclusion: Oral magnesium supplementation modestly improved insulin sensitivity, post-load glucose, and lipid profiles in prediabetic adults with excellent safety and tolerability. Magnesium may serve as a cost-effective adjunct to lifestyle interventions for diabetes prevention, though larger standardized trials are needed. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01853-9.
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