ArticleMediterranean journal of hematology and infectious diseases2026
Dynamic multiplex cytokine profiling to identify risk factors for Lung Consolidation and Necrotizing Transformation in Children with
Article in Mediterranean journal of hematology and infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Association Between Pre-Admission 48-Hour Fever Burden and Outcomes in Pediatric Mycoplasma Pneumoniae Infection.Mediterranean journal of hematology and infectious diseases · 2026Article
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2 authors.
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Abstract
Background: Radiologic complications of pediatric Methods: A retrospective cohort (Oct 2022-Sep 2024) of hospitalized children with PCR-confirmed MPP. Multiplex cytokines (including IL-6, IL-10, CXCL10/IP-10) were assayed from residual samples at admission (T0) and days 3-5 (T1). NP analyses were conditional on undergoing computed tomography (CT). Primary outcomes were WHO end-point CXR consolidation ≤14 days and CT-defined NP ≤28 days. Full-cohort 14-day CXR-consolidation risk (admission), post-T1 consolidation risk among event-free children (day 3-5 landmark), and 28-day NP risk conditional on being scanned. Penalized logistic models evaluated T0 and Δ(T0-T1) predictors among children event-free at T1, with AUC (bootstrap-corrected) and BH-FDR control. Results: Of 286 enrollments, 268 were analyzed; consolidation occurred in 96/268 (35.8%), CT was performed in 124/268 (46.3%), and identified NP in 28/124 (22.6%; 10.4% overall). In the Admission model, IL-6 (adjusted OR [aOR] 1.45, 95% CI 1.16-1.83; q=0.01), IP-10 (1.52, 1.21-1.93; q<0.01), and IL-10 (1.28, 1.03-1.60; q=0.04) predicted consolidation (AUC 0.78, 95% CI 0.73-0.83). In event-free children at T1 (n=180), ΔIL 6 (1.40, 1.12-1.76) and ΔIP 10 (1.48, 1.18-1.88) improved discrimination (AUC 0.84, 0.79-0.88). In CT-subset models, T0 IL-6 (1.67, 1.09-2.58) and ΔIL-6 (1.89, 1.22-3.00) were associated with NP (AUC 0.79). Findings were robust in prespecified sensitivity analyses. Conclusions: Admission cytokines and early rises, especially IL-6 and IP-10, enable pragmatic early risk stratification for consolidation, with ΔIL-6 also signaling NP risk in the CT-scanned subset. These results support external validation of a cytokine-based tool to inform imaging and triage.
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