ArticleThe journal of venomous animals and toxins including tropical diseases2026
A venom fraction from the Philippine tarantula (
Article in The journal of venomous animals and toxins including tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Spider venoms are rich natural sources of bioactive chemicals ranging from low-molecular-mass compounds to larger molecules such as low molecular mass peptides, proteins, and enzymes. Some compounds have been reported to exhibit neuroactivity and show potential as therapeutic agents against neurological disorders. Thus, this study analyzed the neurobehavioral effects of selected venom fractions from Philippine tarantula species compared to FDA-approved drugs targeting neuroreceptors, ion channels, and enzymes. Methods: The venom was collected from the tarantula by electrostimulation and fractionated by reverse-phase high-performance liquid chromatography (RP-HPLC). Nine of the eleven fractions were subjected to neurobehavioral analysis using zebrafish ( Results: Preliminary screening of all the fractions revealed that Fraction 1 with 0.1 µg/µL exhibited donepezil-like behavior based on similar rapid-swimming movement from 0 to 31 time intervals, Fraction 4 with 0.1 µg/µL concentration exhibited diazepam-like behavior due to non-significant differences in its time spent on top of the tank ranging from20 to 40 minutes, and Fraction 8 with 0.1 µg/µL concentration exhibited lidocaine-like behavior based on both rapid swimming movement and time spent on top of the tank. Fractions 1, 4, and 8 were further evaluated by determining their dose-dependent response, which follows the effect of their corresponding positive control. Analysis of Fraction 1 resulted in the annotation of several non-peptidic components 4-OH-PhLac434 and its isomer using VenoMS and isopimaric acid, palmitamide, 9-octadecenamide, and 13-docosenamide as putative compounds present in this spider venom using GNPS. Conclusion: Overall, the fractions of venom from the
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