ArticleAesthetic surgery journal. Open forum2026
Host Biologic Response to Acellular Dermal Matrices of Human and Porcine Origin.
Article in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acellular dermal matrices (ADMs) originate from various tissues and are manufactured by different processes, which can influence material properties that affect host response upon implantation. Objectives: The aim of the study was to compare material properties and host responses to ADMs derived from human or porcine dermis. Methods: The morphology of commercially available ADMs (human-derived AlloDerm [hADM], porcine-derived Strattice Pliable [pADM-S], and porcine-derived Artia [pADM-A]) was evaluated through bright-field and scanning electron microscopy and compared with unprocessed human and porcine dermis. Collagen melting temperatures were assessed through differential scanning calorimetry. Host responses to ADMs were assessed in rat (pADM-A and pADM-S) and nonhuman primate (NHP) models (pADM-A, pADM-S, and hADM). Histologic responses were evaluated for inflammation, fibroblast infiltration, and revascularization. Results: Morphologically, the extracellular matrix structures of hADM, pADM-A, and native human dermis were similarly loose, whereas the structures of pADM-S and native porcine dermis were tighter. Collagen melting temperatures were similar across all samples. Following 20 h exposure to collagenase enzyme, hADM retained the most undigested collagen, followed by pADM-A, then pADM-S. Following 2 and 4 weeks of implantation in the rodent and NHP models, pADM-A yielded the most favorable host response with ample cell infiltration, vascularization, and minimal inflammation vs other implanted ADMs. Minimal-to-moderate inflammatory responses were observed for all materials; hADM and pADM-A demonstrated the lowest responses. Conclusions: In both short-term preclinical implantation models, comparable morphologies and biochemistry of pADM-A and hADM allowed for similarly favorable host responses vs pADM-S. All ADMs assessed demonstrated responses consistent with a favorable regenerative mechanism of action. Level of Evidence 4 Therapeutic:
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