Evidence map›Paper›PMID 41641286›Full record

ArticleMicroplastics and nanoplastics2026

Potential toxicity of micro- and nanoplastics in primary bronchial epithelial cells of patients with chronic obstructive pulmonary disease.

I F Gosselink, P Leonhardt, M J Drittij, E Weltjens, P J J Jessen, F G A J van Belleghem, K Smeets, I M Kooter, F J van Schooten, Alexander H V Remels

Abstract read
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In one paragraph

Article in Microplastics and nanoplastics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

I F GosselinkInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
P LeonhardtInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
M J DrittijInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
E WeltjensInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
P J J JessenInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
F G A J van BelleghemResearch Group Zoology: Biodiversity & Toxicology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, 3590 Belgium.
K SmeetsResearch Group Zoology: Biodiversity & Toxicology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, 3590 Belgium.
I M KooterInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
F J van SchootenInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.
Alexander H V RemelsInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Department of Pharmacology and Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, 6229 ER The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The environmental presence of airborne micro- and nanoplastics (MNPs) raises concerns about their impact on the development and progression of respiratory diseases, including chronic obstructive pulmonary disease (COPD). In this study, we investigated the potential toxicity of amorphous, environmentally relevant MNPs in primary bronchial epithelial cells (PBEC) exposed at the air-liquid interface (ALI). Methods: Differentiated PBEC cultures from COPD donors ( Results: All PBEC cultures formed an intact epithelial barrier. However, transepithelial electrical resistance (TEER) and transcript levels of tight junction protein Claudin 4 were lower (FC = 0.36, Conclusion: These results indicate that MNP exposure, especially PA, can induce (sub)toxic effects in PBEC, with substantial inter-donor variability. Whether this impacts COPD development remains to be studied. Supplementary Information: The online version contains supplementary material available at 10.1186/s43591-025-00166-1.

Indexed as

COPDNanoplasticsPolyamidePolypropylenePolyvinylchloride

Identifiers

PMID41641286
PMCPMC12864305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.