Evidence map›Paper›PMID 41641265›Full record

ArticleFrontiers in immunology2025

A secreted C-type lectin in Periplaneta americana functioning in antibacterial activity, innate immune signaling and leg regeneration.

Xiaoxuan Liu, Nan Sun, Shuang Geng, Shuqi Xian, Xiaojuan Wu, Ying Huang, Yechun Pei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoxuan Liu *School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Nan Sun *School of Tropical Agriculture and Forestry, Hainan University, Haikou, China.
Shuang GengSchool of life science, Shanxi University, Datong, China.
Shuqi XianSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Xiaojuan WuSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Ying HuangSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Yechun PeiSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: C-type lectins are important pattern-recognition receptors that play essential roles in innate immune responses by recognizing pathogen-associated molecular patterns. However, their biological functions in Methods: Two PaSCLec isoforms predicted by RNA-seq, designated PaSCL-Ad and PaSCL-Reg, were identified using Rapid Amplification of cDNA Ends (RACE) and Nanopore sequencing. Tissue-specific expression and inducible expression following bacterial challenge were analyzed. Recombinant PaSCL-Ad and PaSCL-Reg proteins were produced to examine their binding activities to microbial polysaccharides, bacterial agglutination, antimicrobial effects, and membrane-disruptive activity. Hemocyte phagocytosis was evaluated by immunocytochemical analysis. RNA interference was employed to assess the role of PaSCLec in immune regulation and leg regeneration, followed by transcriptional analyses. Results and Discussion: Total PaSCLec (PaSCL-Ad and PaSCL-Reg) was most highly expressed in the hemolymph and was significantly upregulated after challenge with

Indexed as

ExtremitiesImmunity, InnateInsect ProteinsLectins, C-TypePeriplanetaRegenerationAnimalsAnti-Bacterial AgentsHemocytesInnate Immunity RecognitionPhagocytosisSignal TransductionAnti-Bacterial AgentsInsect ProteinsLectins, C-TypeC-type lectinsimmune responsePaSCLecperiplaneta americanaregeneration

Identifiers

PMID41641265
PMCPMC12864434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.