ArticleFrontiers in medicine2025
Correlation between systemic inflammation markers and insulin resistance in type 2 diabetes mellitus patients and its diagnostic value analysis.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association and predictive value of systemic immune-inflammation index and body mass index in cervical ossification of the posterior longitudinal ligament.Frontiers in molecular biosciences · 2026Article
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8 authors.
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Abstract
Background: Insulin resistance (IR) is a central pathophysiological feature of type 2 diabetes mellitus (T2DM) and is closely associated with chronic low-grade inflammation. Simple systemic inflammatory markers derived from routine laboratory testing may reflect this inflammatory-metabolic state; however, their clinical relevance in relation to IR remains incompletely defined. Methods: In this retrospective cross-sectional study, 2,177 patients with T2DM and 327 age- and sex-matched healthy controls were included. Insulin resistance was assessed using the homeostasis model assessment index (HOMA-IR), and patients with T2DM were classified as insulin-resistant or non-insulin-resistant based on established criteria. Systemic inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), and white blood cell count (WBC), were analysed. Associations with IR were examined using correlation analysis and multivariable logistic regression. Receiver operating characteristic (ROC) curve analysis was performed to evaluate discriminative performance. Results: Levels of NLR, hs-CRP, and WBC were significantly higher in patients with T2DM than in healthy controls and were further elevated in insulin-resistant patients. All three markers were positively correlated with HOMA-IR, with NLR showing the strongest association ( Conclusion: Systemic inflammatory markers, particularly NLR, are significantly associated with insulin resistance in patients with T2DM. Although the discriminative performance of NLR was modest, its simplicity, low cost, and availability from routine complete blood counts support its potential role as a complementary marker associated with IR rather than a standalone diagnostic tool. Prospective studies are needed to clarify temporal relationships and validate these findings across diverse populations.
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