SynthesisFrontiers in medicine2025
Impact of physical exercise interventions on functional fitness in older adults.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating exercise and nutrition to combat frailty: a systematic review of multidomain interventions in aging populations.Frontiers in nutrition · 2026Pooled it
- Physical activity and sitting over 9 years of the Women's Health Initiative Strong & Healthy (WHISH) randomized physical activity intervention trial in older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Usage of the Tablet-Based "Keep On Keep Up" Digital Program and Resulting Changes in Physical Capacity and Real-World Walking in Community-Dwelling Older Adults: Process Evaluation.JMIR formative research · 2026Trial
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Aging is associated with a progressive decline in functional fitness-the physiological capacity for performing everyday activities safely and independently-which compromises autonomy in older adults. Maintaining functional fitness is crucial for preserving independence and promoting healthy aging. This systematic review synthesized evidence from recent randomized and controlled clinical trials to evaluate the effects of physical exercise on functional fitness in people aged ≥65 years. Methods: A systematic search was conducted in three major databases (MEDLINE, PMC, and PubMed Central Canada) using comprehensive sets of keywords and MeSH terms related to "older adults" and specific exercise modalities (e.g., endurance, strength, resistance training). The search included studies published between 2015 and 2024. After duplicate removal and application of eligibility criteria, 95 studies were included. A meta-analysis was not performed due to substantial methodological heterogeneity among the included studies. Results: The synthesized evidence indicates that most exercise interventions improved functional fitness outcomes in older adults. Multicomponent programs, resistance training, and supervised protocols were particularly effective. Significant benefits were observed in muscular strength (e.g., ~20-40% improvement in 30-second chair stand test), mobility (e.g., ~1.0-2.5-second reduction in Timed Up and Go test time), balance, and gait speed (e.g., ~0.08-0.15 m/s increase). Positive effects on body composition, such as increased lean mass, were also reported. However, effects on cognitive function were inconsistent. Interventions lasting more than 12 weeks and demonstrating high adherence were associated with more favorable outcomes. Discussion: Structured, well-designed exercise programs tailored to the needs and capacities of older adults represent effective, non-pharmacological strategies to enhance functional independence and promote healthy aging. The observed improvements in muscular strength, mobility, balance, and gait speed underscore the value of regular physical activity in mitigating age-related functional decline. However, the heterogeneity of interventions and limitations in the quality appraisal of included studies should be considered when interpreting these findings. Future research should focus on standardizing intervention protocols and exploring long-term adherence and sustainability of exercise programs in older populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.