ArticleRSC advances2026
A Ru(ii)-arene complex with promising anti-Aβ activity.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Agents that target the amyloid-beta (Aβ) peptide associated with Alzheimer's disease have seen renewed interest following recent the clinical success of monoclonal antibody therapeutics. Metal complexes are particularly promising for development, given their relative ease of preparation and modular scaffold. Additionally, Aβ has been shown to coordinate endogenous metal ions in solution, while metal complexes can exploit this affinity, thereby modulating the aggregation of the peptide. Herein, a series of five ruthenium(ii)-arene complexes with 1,10-phenanthroline (phen) ligands were prepared and studied for their respective abilities to impact the aggregation of Aβ. Overall, the complex with the 4,7-diamino-1,10-phenanthroline ligand (RuPA) had the greatest impact on Aβ aggregation. Furthermore, this complex also displayed interactions with imidazole in aqueous media, which suggests that coordinate interactions with the peptide occur
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