Evidence map›Paper›PMID 41641220›Full record

ArticleWorld journal of psychiatry2026

Characteristics and functions of the gut microbiome in monozygotic twins with autism spectrum disorders of varying severity.

Yi-Yang Huang, Chun-Yan Li, Yun Li, Hui Fang, Xiao-Yan Ke

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Article in World journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi-Yang HuangDepartment of Child Mental Health, Children's Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
Chun-Yan LiDepartment of Clinical Psychology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, Jiangsu Province, China.
Yun LiChild Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
Hui FangChild Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
Xiao-Yan KeChild Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China. kexynj@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by pronounced behavioral heterogeneity and individual variability. Growing evidence indicates a strong association between gut microbiota and ASD; however, differences in microbial functions across varying levels of ASD severity remain poorly understood. Monozygotic twins (MZs) provide an appropriate model for examining the influence of nonshared environmental factors in ASD.

aimTo investigate the effects of the gut microbiome in MZs with ASD using 16S ribosomal RNA sequencing.

methodsParticipants were recruited from the Chinese MZs with autism spectrum disorder (MZCo-ASD) cohort and stratified into mild MZCo-ASD and severe MZCo-ASD (MZCo-ASD-H) groups based on their Childhood Autism Rating Scale scores. Fecal samples were collected and analyzed using 16S ribosomal RNA sequencing.

resultsAlthough overall microbial diversity did not differ significantly between the groups, gut microbiota composition was notably altered. At the genus level,

conclusionDespite similar overall diversity, children with severe ASD exhibited distinct gut microbiota structures and functional impairments. The enrichment of

Indexed as

Autism spectrum disorderg-PorphyromonasGut microbiomeMonozygotic twinsNonshared environmental factors

Identifiers

PMID41641220
PMCPMC12865458

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