Evidence map›Paper›PMID 41641077›Full record

ArticleJBMR plus2026

Inhibition of FGFR signaling with infigratinib improves linear bone growth in the female

Alexander Kot, Caroline Wight, Roya Bagheri, Davis Wachtell, Alma Rios, Benjamin Bober, Cora Chun, Pavel Krejci, Jennifer Zieba, Deborah Krakow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander KotOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.ORCID https://orcid.org/0000-0003-2355-0630
Caroline WightOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.
Roya BagheriOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.
Davis WachtellOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.ORCID https://orcid.org/0000-0002-8369-3919
Alma RiosOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.
Benjamin BoberOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.
Cora ChunOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.
Pavel KrejciDepartment of Biology, Faculty of Medicine, Masaryk University, Brno, 625 00, Czech Republic.ORCID https://orcid.org/0000-0003-0618-9134
Jennifer ZiebaOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.ORCID https://orcid.org/0000-0003-1650-1830
Deborah KrakowOrthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, United States.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
UCLA-Caltech Medical Scientist Training ProgramT32GM152342 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Olujimi A Ajijola, David Wayne Dawson · 2024 to 2026
$5.3M
Genetic determinants of endoplasmic reticulum stress in OI and its consequences on cellular receptorsF30HD113414 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Kot · 2024 to 2026
$151k
NICHD NIH HHS F30 HD113414NIGMS NIH HHS T32 GM008042NIGMS NIH HHS T32 GM152342
6 · The paper itself

Abstract

Osteogenesis imperfecta, a genetically heterogeneous disorder, is characterized by brittle bones with recurrent fractures as well as short stature. A recent study investigating cellular signaling in growth plate chondrocytes identified an increased expression of FGF receptors and elevated FGF signaling. We inhibited FGF receptor activation with the small molecule infigratinib in growing

Indexed as

boneFGF signalinggrowthinfigratinibosteogenesis imperfecta

Identifiers

PMID41641077
PMCPMC12866916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.