Evidence map›Paper›PMID 41640993›Full record

ReviewFood science & nutrition2026

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights.

Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn-Han Lee, Imane Chamkhi, Abdelhakim Bouyahya

Abstract readReview
In one paragraph

Review in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamza ElhrechLaboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Oumayma AguerdLaboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Meriem El FessikhLaboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Zouhair EssahliLaboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.
Taoufiq BenaliLaboratory of Ecotoxicology, Bioresources, and Coastal Geomorphology, Polydisciplinary Faculty of Safi Cadi Ayyad University Safi Morocco.
Waleed Al AbdulmonemDepartment of Pathology, College of Medicine Qassim University Buraydah Saudi Arabia.ORCID https://orcid.org/0000-0003-2984-9262
Learn-Han LeeNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome Research Group, Research Centre for Life Science and Healthcare, Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute (CBI) University of Nottingham Ningbo China Ningbo China.ORCID https://orcid.org/0000-0002-8589-7456
Imane ChamkhiGeobiodiversity and Natural Patrimony (GEOPAC), Scientific Institute Mohammed V University in Rabat Rabat Morocco.ORCID https://orcid.org/0000-0002-5865-7713
Abdelhakim BouyahyaLaboratory of Human Pathologies Biology, Faculty of Sciences Mohammed V University in Rabat Rabat Morocco.ORCID https://orcid.org/0000-0001-9317-1631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional Chinese medicine (TCM) has garnered considerable attention due to its multifaceted therapeutic potential, characterized by a broad spectrum of pharmacological activities, multiple biological targets, and a generally favorable safety profile. Atractylone, a bioactive sesquiterpenoid, has been noted to exhibit numerous pharmacological effects, including cytotoxic, antimicrobial, anti-inflammatory, antiviral, anticancer, antioxidant, neuroprotective, and gastroprotective activities. The isolation and structural characterization of this compound are essential for optimizing its pharmacological applications and unlocking its full therapeutic potential. Despite its promising bioactivity, to our knowledge, no comprehensive review has yet been dedicated to summarizing the current state of research on Atractylone. To tackle this gap, we conducted a systematic review following the PRISMA guidelines to define a clear research question and methodology. A comprehensive literature search was performed using PubMed, Scopus, Web of Science, and Google Scholar to collect all available information on Atractylone. This review aims to furnish a detailed analysis of its natural sources, biosynthetic pathways, and biological activities. By summarizing current knowledge, this article establishes a foundation for future research and encourages further exploration of Atractylone's therapeutic applications.

Indexed as

anticanceratractyloneinflammationneuroprotectivepharmacokineticsystematic review

Identifiers

PMID41640993
PMCPMC12864542

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.