Evidence map›Paper›PMID 41640867›Full record

ArticleWorld journal of gastroenterology2026

Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease

Ting Gao, Kang-Peng Zhong, Jun-Zhuo Wang, Yi Chen, Chun-Xiao Li

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In one paragraph

Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ting GaoDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China.
Kang-Peng ZhongDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China.
Jun-Zhuo WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China.
Yi ChenDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Chun-Xiao LiDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, Zhejiang Province, China. 11418130@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior studies indicate that allyl isothiocyanate (AITC) alleviates metabolic dysfunction-associated steatotic liver disease (MASLD). The vitamin D receptor (VDR) is known to exert protective effects in MASLD; however, whether AITC alleviates MASLD through VDR remains unclear.

aimTo clarify the function and underlying mechanisms of AITC in MASLD

methodsAML-12 cells were exposed to 300 μM palmitate acid (PA) for 24 hours to establish an

resultsTo establish an

conclusionAITC provides a robust molecular basis for improving MASLD by activating hepatic VDR and driving the downstream HNF-4α/MTTP/ApoB signaling pathway. This pathway reduces hepatic lipid accumulation, promotes FA β-oxidation, and improves insulin resistance, establishing AITC as a promising treatment for MASLD.

Indexed as

Fatty LiverHepatocytesIsothiocyanatesNon-alcoholic Fatty Liver DiseaseReceptors, CalcitriolAnimalsCell LineHumansInsulin ResistanceLipogenesisLiverMiceOxidation-ReductionSignal Transductionallyl isothiocyanateIsothiocyanatesReceptors, CalcitriolAllyl isothiocyanateFatty acid β-oxidationLipid synthesisMetabolic dysfunction-associated steatotic liver diseaseVitamin D receptor

Identifiers

PMID41640867
PMCPMC12865401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.