Evidence map›Paper›PMID 41640827›Full record

ArticleSurgical case reports2026

Unicentric Castleman Disease Presenting with a Ruptured Pseudoaneurysm within the Tumor: A Case Report.

Toshiki Matsui, Kohei Kawagita, Kazuki Nomura, Maki Hamaguchi, Natsuki Hashiba, Naoya Tsuji, Hirotaka Shibuya, Yosuke Yamauchi, Daisuke Noguchi, Keita Sato and 11 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Toshiki MatsuiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Kohei KawagitaDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Kazuki NomuraDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Maki HamaguchiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Natsuki HashibaDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Naoya TsujiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Hirotaka ShibuyaDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Yosuke YamauchiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Daisuke NoguchiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Keita SatoDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Yoshihisa TamuraDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Ryosuke DesakiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Koji KumamotoDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Koji FujiiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Koji TakahashiDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Tsukasa KusutaDepartment of Surgery, Ise Red Cross Hospital, Ise, Mie, Japan.
Toji MurabayashiDepartment of Gastroenterology, Ise Red Cross Hospital, Ise, Mie, Japan.
Shinya SugimotoDepartment of Gastroenterology, Ise Red Cross Hospital, Ise, Mie, Japan.
Junji UrakiDepartment of Radiology, Ise Red Cross Hospital, Ise, Mie, Japan.
Mari UedaDepartment of Pathology, Ise Red Cross Hospital, Ise, Mie, Japan.
Tadashi YabanaDepartment of Pathology, Ise Red Cross Hospital, Ise, Mie, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCastleman disease is a lymphoproliferative disorder of unknown etiology, typically reported as a hypervascular tumor. Here, we report the first known case of unicentric Castleman disease in which a pseudoaneurysm developed within the tumor and ruptured spontaneously. CASE PRESENTATION: A 55-year-old male was hospitalized due to the sudden onset of epigastric pain. Contrast-enhanced CT revealed a 60-mm hypovascular mass located on the dorsal side of the pancreas, with evidence of extravasation within the tumor. Emergency angiography was performed; nonetheless, the pseudoaneurysm was not clearly identified. The patient was administered antihypertensive therapy and discharged. He was subsequently referred to our hospital for further examination and treatment. Upon reviewing the angiographic images obtained at the previous hospital, a pseudoaneurysm was retrospectively identified in a small branch of the splenic artery. Follow-up contrast-enhanced CT at our hospital showed slight tumor shrinkage and resolution of the extravasation. Although the ventral region of the tumor showed marked enhancement, no noticeable enhancement was observed in the dorsal region. Based on imaging findings, a pancreatic neuroendocrine tumor was suspected. While endoscopic ultrasonography fine-needle tissue acquisition was performed twice, a definitive diagnosis could not be made. Suspecting a pancreatic neuroendocrine tumor, we recommended surgery. The patient underwent anterior radical antegrade modular pancreatosplenectomy. Histopathological findings showed that the tumor had no continuity with the pancreatic tissue and was composed of 2 lesions. The ventral portion of the tumor showed lymphoid tissue proliferation with follicular hyperplasia. Blood vessels traversed the lymphoid follicles, and blood vessel walls showed hyalinization and thickening. No atypical lymphocytes were observed. The dorsal portion of the tumor was necrotic. Based on these findings, the patient was diagnosed with unicentric Castleman disease (hyaline vascular type). At the time of writing, there was no recurrence of the disease 24 months after surgery.

conclusionsIn Castleman disease, as demonstrated in this case, pseudoaneurysm formation may occur. In cases presenting with an intratumoral pseudoaneurysm, Castleman disease should be considered in the differential diagnosis, and angiography should be included for further evaluation and preoperative treatment.

Indexed as

Castleman diseasehypervascular tumorretroperitoneumruptured pseudoaneurysmtranscatheter arterial embolization

Identifiers

PMID41640827
PMCPMC12867554

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.