ArticleRheumatology advances in practice2026
Maternal and perinatal outcomes in vasculitis: a 15-year study at a Portuguese tertiary multidisciplinary centre.
Article in Rheumatology advances in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To evaluate maternal and perinatal outcomes in women with vasculitis and identify risk factors for adverse pregnancy outcomes (APOs). Methods: This retrospective study included pregnant women with systemic vasculitis followed between 2009 and 2024 at a multidisciplinary tertiary centre. Clinical data on patient characteristics, disease activity (remission or relapse), treatment and pregnancy outcomes were collected. APOs comprised miscarriage, stillbirth, preterm birth, foetal growth restriction (FGR), small for gestational age (SGA) and pre-eclampsia. Associations between clinical variables and APOs were assessed using univariate analysis and multivariate binary logistic regression. Results: A total of 39 pregnancies occurred in 28 women with vasculitis. Most pregnancies (92.3%) occurred during clinical remission. The most frequent vasculitis subtypes were Behçet's disease ( Conclusion: Pregnancy in women with vasculitis is often successful in the context of clinical remission at conception. Our findings are exploratory but suggest that prednisolone use and disease relapse may increase the risk of APOs, highlighting the importance of preconception counselling and multidisciplinary care throughout pregnancy.
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