ArticleFrontiers in nutrition2025
Non-linear association between metabolic score for insulin resistance and diabetes mellitus in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Background: Although the link between the metabolic score for insulin resistance (METS-IR) and diabetes mellitus (DM) is well-established in general populations, it remains underexplored in normal-weight middle-aged and old adults-an often-overlooked group in metabolic research. Therefore, this study investigated the association between METS-IR and diabetes in this specific population. Methods: A retrospective cohort study was conducted using data from the Rich Healthcare Group database, including 23,692 normal-weight (body mass index: 18.5-23.9 kg/m Results: Higher METS-IR values were significantly correlated with greater diabetes risk during follow-up. In the model 3, each 1-unit rise in METS-IR corresponded to a 12% increase in diabetes risk (HR: 1.12, 95% CI: 1.10, 1.14). The analysis revealed a non-linear association, with a critical inflection point at a METS-IR of 37.24. Below this threshold, risk rose more sharply (HR: 1.18, 95% CI: 1.14, 1.21 per unit), whereas above the threshold, the association was attenuated (HR: 0.96, 95% CI: 0.89, 1.04). Subgroup analyses showed largely consistent findings across strata. Conclusions: Among normal-weight middle-aged and older Chinese adults, METS-IR exhibits a positive, non-linear relationship with DM risk. Maintaining a lower METS-IR may help prevent the development of DM.
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