Evidence map›Paper›PMID 41640732›Full record

ArticleCase reports in infectious diseases2026

Human-to-Human Transmission of Severe Fever With Thrombocytopenia Syndrome Resulting in Fatal Cases: A Case Series.

Lu Yao, Xiaobo Yang, Xuehui Gao, Yin Yuan, Chang Li, Chenggang Gao, Huaqing Shu, Xiaojing Zou, Ruiting Li, Jiqian Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lu YaoDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Xiaobo YangDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Xuehui GaoDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Yin YuanDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Chang LiDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Chenggang GaoDepartment of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China, scu.edu.cn.
Huaqing ShuDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Xiaojing ZouDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.
Ruiting LiDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.ORCID https://orcid.org/0000-0001-8041-1050
Jiqian XuDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.ORCID https://orcid.org/0009-0000-7854-8744
You ShangDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, hust.edu.cn.ORCID https://orcid.org/0000-0003-4097-6131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), primarily a tick-borne disease, can also cause fatal human-to-human transmission. This report analyzes a cluster of six SFTS cases identified in China in 2022, involving one index patient and five secondary infections, with an overall mortality of 83%. All secondary cases occurred in elderly individuals (aged 66-85 years) following unprotected exposure to the index patient's body fluids during bedside care or traditional postmortem rituals, without documented tick bites. The high fatality rate underscores the potential severity of secondary transmission, particularly among elderly adults. More critically, this outbreak exposes systemic delays in early diagnosis even within an endemic area, highlighting fundamental gaps in the clinical management of undifferentiated fever. Effective prevention, therefore, relies on establishing a clinical system for early detection, rapid diagnosis, and prompt isolation while implementing culturally adapted community interventions to reliably interrupt transmission.

Indexed as

clinical managementdiagnostic delayelderlyhuman-to-human transmissionSFTS

Identifiers

PMID41640732
PMCPMC12864538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.