Evidence map›Paper›PMID 41640672›Full record

ArticleLaryngoscope investigative otolaryngology2026

A Novel Imaging Technique to Identify Vocal Fold Scar Formation.

Solymar Torres Maldonado, Alice Yu, Yazeed Alhiyari, Rodell Santuray, Larissa Nicolas, Maie St John, Jennifer L Long

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Novel Imaging Technique to Identify Vocal Fold Scar Formation.Laryngoscope investigative otolaryngology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Solymar Torres MaldonadoDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.
Alice YuDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.
Yazeed AlhiyariDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.
Rodell SanturayDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.
Larissa NicolasDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.ORCID https://orcid.org/0009-0009-0886-6849
Maie St JohnDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.ORCID https://orcid.org/0000-0001-7068-9534
Jennifer L LongDepartment of Head and Neck Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles California USA.ORCID https://orcid.org/0000-0002-4185-2328

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Tissue engineering to regenerate functional vocal fold after scarring or tissue lossR01DC016959 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONG, JENNIFER L · 2018 to 2022
$3.7M
Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
NCATS NIH HHS UL1 TR001881NIDCD NIH HHS R01 DC016959NIDCD NIH HHS R25 DC020151
6 · The paper itself

Abstract

Introduction: A non-invasive test to accurately diagnose and quantify vocal fold (VF) scarring from other confounding pathologies would be advantageous to reduce the need for operative diagnostic laryngoscopy. Dynamic optical contrast imaging (DOCI) technology uses tissue autofluorescence to obtain real-time information of tissue composition. In this study, we describe a novel application of DOCI to identify scar tissue formation in rabbit VFs. Methods: Rabbits underwent endoscopic unilateral VF cordectomy to induce scar formation. After 2 months, VFs were excised and a bench-top DOCI (UCLA) system was employed to capture images from sections. Results were verified with histologic staining for scar tissue. Results: The DOCI system was capable of distinguishing healthy VF from contralateral scarred VF with discriminating power at the 405 low-pass filter (LPF), 440, 460-532, and 560-580 nm wavelengths ( Conclusion: Our study demonstrated that DOCI technology can discriminate between normal and scarred VFs noninvasively and in real time with similar accuracy to that of histological analysis. This work lays the foundation for the development of a DOCI-based endoscope for diagnosis and quantification of VF scar formation as well as a tool to measure treatment response.

Indexed as

DOCInoninvasive imagingvocal fold scarring

Identifiers

PMID41640672
PMCPMC12864159

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.