ArticleAdvanced biomedical research2025
RIG-I and MDA5 Expression Levels in the Inflamed Pulp Tissues of Dental Caries.
Article in Advanced biomedical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pulp inflammation is one of the primary side effects of dental caries. MDA5 (melanoma differentiation-associated protein 5) and RIG-I (retinoic acid-inducible gene I) are two intracellular receptors that activate inflammatory transcription factors via recognition of damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). The aim of this Materials and Methods: mRNA levels of MDA5 and RIG-I were assessed in 50 inflamed versus 50 healthy pulps. Total RNA extraction and cDNA synthesis were performed and expression levels of MDA5 and RIG-I were evaluated using real-time PCR. Results: The results revealed that the mRNA levels of MDA5, but not RIG-I were significantly different in inflamed compared with healthy pulps. Furthermore, there was no significant difference in RIG-I expression taken from inflamed or healthy pulps of men and women. On the other hand, MDA5 expression was significantly upregulated in men, compared to women with pulpitis. Conclusions: The results suggest that MDA5 participates in the inflammation of pulps following caries. In addition, it may be hypothesized that MDA5 expression can be sex-dependent in the inflamed pulps.
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