Evidence map›Paper›PMID 41640631›Full record

ArticleAmerican journal of ophthalmology case reports2026

A giant bleb over a non-valved tube successfully treated with compression sutures.

Mariana Fonseca, Chhavi Saini, Milica A Margeta

Abstract read
In one paragraph

Article in American journal of ophthalmology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariana FonsecaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Chhavi SainiDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Milica A MargetaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Funding

Mechanisms of microglial neuroinflammatory response in glaucomaR01EY035312 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Milica Margeta · 2023 to 2026
$1.9M
NEI NIH HHS R01 EY035312
6 · The paper itself

Abstract

Purpose: To report a rare case of an anteriorly enlarged giant bleb following Ahmed ClearPath 350 glaucoma drainage device implantation, successfully treated with compression sutures. Observations: A 50-year-old man with a history of primary open angle glaucoma and multiple prior glaucoma procedures presented with a progressively enlarging inferonasal conjunctival bleb in the right eye, six months after Ahmed ClearPath 350 implantation. Examination revealed visual acuity (VA) of 20/40, intraocular pressure (IOP) of 6 mmHg, and a large, elevated, fluid-filled conjunctival bleb. While bleb formation is a desired outcome following glaucoma drainage device (GDD) implantation and trabeculectomy, the increasingly large size of this bleb caused discomfort, worsening vision, and difficulty closing the eye. Due to its rare nature, there was little consensus available regarding treatment. Compression sutures were placed in attempt to flatten the bleb. At one-week follow-up, vision and discomfort improved and slit-lamp examination revealed a markedly flatter bleb. Sutures were sequentially removed via slit-lamp during the one-month and two-month postoperative visits. At one-year follow-up, VA was 20/25, IOP was 6 mmHg, and slit lamp examination revealed a completely flattened inferonasal bleb. Conclusions and importance: This case highlights a rare presentation of a giant inferonasal conjunctival bleb developing several months after Ahmed ClearPath 350 implantation. The successful use of compression sutures suggests they may be a viable treatment option for similar post-GDD implantation bleb complications.

Indexed as

Ahmed ClearPathCase reportCompression suturesGiant blebGlaucoma drainage device

Identifiers

PMID41640631
PMCPMC12865611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.