Evidence map›Paper›PMID 41640626›Full record

ArticleBiological psychiatry global open science2026

Behavioral and Prefrontal Circuit Deficits in a Newly Developed

MacKenzie A Howard, Mendee A Geist, Gregory J Ordemann, Alena Kizimenko, Dominic M Balice, F Isaac Guillén, Emmanuella Bassey, Polina Lyuboslavsky, Audrey C Brumback

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

MacKenzie A HowardDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Mendee A GeistDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Gregory J OrdemannDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Alena KizimenkoDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Dominic M BaliceDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
F Isaac GuillénDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Emmanuella BasseyDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Polina LyuboslavskyDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.
Audrey C BrumbackDepartment of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.

Funding

Functional architecture of the mediodorsal thalamusR01MH131857 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRUMBACK, AUDREY CHRISTINE · 2023 to 2025
$2.3M
NIMH NIH HHS R01 MH131857
6 · The paper itself

Abstract

Background: SET binding protein 1 ( Methods: We used open field, 3-chamber, and Y-maze behavioral tests to measure activity, social interest, and spatial learning, respectively. We used whole-cell current clamp recordings from medial prefrontal cortex (mPFC) layer-5 extratelencephalic projection neurons in ex vivo slices to measure cell intrinsic and spike properties. We used morphological reconstruction to measure dendritic arborization in recorded neurons. Results: Conclusions: These data show that

Indexed as

Attention-deficit/hyperactivity disorderAutism spectrum disorderBehaviorElectrophysiologyNeurodevelopmental disorder

Identifiers

PMID41640626
PMCPMC12865576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.