Evidence map›Paper›PMID 41640618›Full record

ArticleWorld journal of gastroenterology2026

Targeting Jun N-terminal kinase phosphorylation: A human-derived hepatoprotective peptide human liver transplantation peptide 1 attenuates hepatic ischemia-reperfusion injury.

Hui-Wen Xie, Qun Bao, Zi-Xuan Chen, Xiang-Min Zhang, Xi-Yu Liu, Rui Wang, Yue-Song Cai, Peng Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui-Wen XieDepartment of Medicine, Shanghai Jiao Tong University, Shanghai 200336, China.
Qun BaoDepartment of General Surgery, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Zi-Xuan ChenDepartment of Medicine, Shanghai Jiao Tong University, Shanghai 200336, China.
Xiang-Min ZhangDepartment of Anesthesiology, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200336, China.
Xi-Yu LiuDepartment of Medicine, Shanghai Jiao Tong University, Shanghai 200336, China.
Rui WangHongqiao International Institute of Medicine, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Yue-Song CaiCollege of Medicine, Yanbian University, Yanbian 133002, Jilin Province, China.
Peng SunDepartment of General Surgery, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. surgeonpeng@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatic ischemia-reperfusion injury (HIRI) is a major complication in liver transplantation with limited treatment options. Peptidomics offers a promising approach to discover therapeutic peptides.

aimTo identify novel peptides from human liver transplants that could mitigate HIRI and preliminarily explore their mechanisms.

methodsLiver samples from six transplant patients were analyzed using nano-liquid chromatography-tandem mass spectrometry. A candidate peptide, human liver transplantation peptide 1 (HLTP1), was screened in a murine HIRI model and validated

resultsHLTP1 was identified as a protective peptide. It reduced liver damage and apoptosis in mice, enhanced cell viability and proliferation, and decreased apoptosis in AML12 cells. Mechanistically, HLTP1 inhibited JNK phosphorylation, and its effects were reversed by JNK activation.

conclusionHLTP1 alleviates HIRI by inhibiting JNK-mediated apoptosis, representing a potential therapeutic strategy for liver transplantation.

Indexed as

JNK Mitogen-Activated Protein KinasesLiverLiver TransplantationPeptidesReperfusion InjuryAnimalsApoptosisCell LineCell ProliferationDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLPhosphorylationSignal TransductionJNK Mitogen-Activated Protein KinasesPeptidesApoptosisHepatic ischemia-reperfusion injuryJun N-terminal kinase phosphorylationPeptidePeptidomics

Identifiers

PMID41640618
PMCPMC12865378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.