Evidence map›Paper›PMID 41640607›Full record

ArticleWorld journal of gastroenterology2026

Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity.

Yun-Chu Chen, Meng-Tzu Weng, Feng-Pai Tsai, Zhi-Che Chen, Hsin-Yun Wu, Chien-Chih Tung, Chun-Ying Wang, Shu-Chen Wei

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Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yun-Chu ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Meng-Tzu WengDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Feng-Pai TsaiDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Zhi-Che ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Hsin-Yun WuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Chien-Chih TungDepartment of Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, Taipei 100, Taiwan.
Chun-Ying WangDepartment of Medical Research, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu 300, Taiwan.
Shu-Chen WeiDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. shuchenwei@ntu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopy is the gold standard for examining inflammatory bowel disease (IBD), and fecal calprotectin (FC) is a widely used surrogate marker for IBD. However, both methods are considered unpleasant by patients because of their invasiveness and inconvenience. Leucine-rich α-2-glycoprotein (LRG) is a novel serum biomarker that has been previously studied only in Japanese populations.

aimTo evaluate the predictive utility of LRG in a Taiwanese cohort.

methodsPatients with IBD were prospectively enrolled between 2022 and 2024. Serum and stool samples were collected within 1 month of endoscopy, and patient albumin, hemoglobin (Hb), and C-reactive protein (CRP) levels were measured. Active endoscopic disease was defined as a Mayo endoscopic subscore ≥ 2 for ulcerative colitis (UC) or a Simple Endoscopic Score for Crohn's Disease ≥ 6 for Crohn's disease (CD). Correlations and diagnostic performance of biomarkers were analyzed.

resultsA total of 203 patients (100 with UC and 103 with CD) were enrolled. LRG was positively correlated with FC and CRP but negatively correlated with Hb and albumin (

conclusionLRG may serve as a supportive biomarker, particularly in combination with other markers, for assessing disease activity in Taiwanese patients with IBD. In patients with UC with normal CRP levels, adding LRG and Hb could enhance the predictive accuracy for endoscopic activity to nearly that of FC.

Indexed as

Colitis, UlcerativeCrohn DiseaseGlycoproteinsAdultAgedBiomarkersColonoscopyC-Reactive ProteinFecesFemaleHumansLeukocyte L1 Antigen ComplexMaleMiddle AgedPredictive Value of TestsProspective StudiesBiomarkersC-Reactive ProteinGlycoproteinsLeukocyte L1 Antigen ComplexLRG1 protein, humanBiomarkersCrohn’s diseaseInflammatory bowel diseaseLeucine-rich α-2-glycoproteinUlcerative colitis

Identifiers

PMID41640607
PMCPMC12865370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.