Evidence map›Paper›PMID 41640585›Full record

ArticleCase reports in urology2026

Uncommon Presentation of Primary Bladder Signet Ring Cell Carcinoma With Peritoneal Carcinomatosis: A Rare Case Report.

Jean Paule Joumaa, Kelly Katherine Karam, Joya Ghaleb, Hilda E Ghadieh, Alaa Korhani

Abstract read
In one paragraph

Article in Case reports in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jean Paule JoumaaDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli, Lebanon, balamand.edu.lb.ORCID https://orcid.org/0009-0000-4393-2252
Kelly Katherine KaramDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli, Lebanon, balamand.edu.lb.ORCID https://orcid.org/0009-0002-6998-6288
Joya GhalebDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli, Lebanon, balamand.edu.lb.ORCID https://orcid.org/0009-0002-5919-2441
Hilda E GhadiehDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli, Lebanon, balamand.edu.lb.ORCID https://orcid.org/0000-0002-7983-2090
Alaa KorhaniDepartment of Urology, Hospital Nini, Tripoli, Lebanon.ORCID https://orcid.org/0009-0004-3394-6107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary signet ring cell carcinoma (SRCC) of the bladder is an exceptionally rare and aggressive malignancy, accounting for only 0.12%-0.6% of all bladder cancers. This case report describes a 54-year-old female who presented with urinary incontinence and abdominal pain, initially misdiagnosed as a urinary tract infection. Imaging revealed suspicious bladder findings, and subsequent cystoscopy with transurethral resection identified SRCC, later confirmed by immunohistochemistry (PD-L1 positive, CDX-2/ER negative). Despite peritoneal carcinomatosis, the patient responded to cisplatin/gemcitabine chemotherapy and immunotherapy, demonstrating tumor shrinkage on follow-up imaging. This case highlights the diagnostic challenges of SRCC due to its nonspecific symptoms and potential histological overlap with other metastatic gastrointestinal tumors. Early recognition and a multidisciplinary approach are critical for improving patient outcomes.

Indexed as

bladder cancerimmunohistochemistryPD-L1peritoneal carcinomatosissignet ring cell carcinomaurinary incontinence

Identifiers

PMID41640585
PMCPMC12867003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.