ArticleFrontiers in cardiovascular medicine2025
Acute effect of cryoballoon pulmonary vein isolation on the signal-averaged P-wave.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06061120 (Non-invasive Differentiation of Supraventricular Tachyarrhythmias by Questionnaire and High-resolution ECG in the Context of Ablation Treatment), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Non-invasive Differentiation of Supraventricular Tachyarrhythmias by Questionnaire and High-resolution ECG in the Context of Ablation Treatment
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Cryoballoon ablation of atrial fibrillation alters a significant amount of vital myocardium contributing to its electrical activity. However, the effect of pulmonary vein isolation (PVI) on the P-wave is unclear. The study aimed to quantify P-wave changes following individual PVI using signal-averaged ECG analysis. Materials and methods: Unfiltered high-resolution (2,000 samples/second) ECGs were obtained for 5 min pre- and post-isolation of each pulmonary vein in 69 participants using 12 standard and 10 additional leads optimized for atrial electrical activity detection. Signal-averaged ECGs were computed and analyzed using custom software in Matlab. This study was registered at ClinicalTrials.gov (Identifier: NCT06061120). Results: Significant changes in ECG parameters were found. Following complete PVI, P-wave terminal force measured in lead V1 (3.08 ± 1.99 vs. 2.63 ± 1.76 mV*ms, Conclusion: The observed changes in signal-averaged P-wave parameters during cryoballoon PVI may indicate acute intraprocedural effects on atrial electrophysiology. These exploratory findings suggest that high-resolution, non-invasive ECG recordings are capable to detect stepwise changes of electrical atrial activity, offering new perspectives for intraprocedural assessment of ablation effects.
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