Relationship between sleep disorders and depression in perimenopausal women in the United States: a cross-sectional survey based on NHANES 2009-2014.

Background: Many studies have found that depression and sleep disorders in perimenopausal women often appear as comorbidities, but its relevance has not been further verified. To clarify the relationship between the two can provide guidance for future clinical research. Methodology: A cross-sectional research was carried out among 1400 women aged 45-55 years who participated in the 2009-2014 national health and Nutrition Examination Survey (NHANES). We estimated unadjusted and adjusted logistic regression models to analyze the relationship between sleep disturbances and other related factors with depression. Results: 18.1% of the 1440 participants had depressive symptoms in the past two weeks. 11.2% had sleep disorder. Compared with women without sleep disorder (14.70%), depression was more common in perimenopausal women who had sleep disorder (44.72%), In the logistic regression model, menopausal women with sleep disturbance suffer from depression were four times more than that without sleep disturbance (odds ratio, 3.798; 95%CI, 2.611-5.525); The difference remained significant after adjusted the effects of covariates (adjusted odds ratio, 3.687; 95% CI, 2.533-5.367). Conclusion: Sleep disorders strongly link to depression in menopausal women. Early intervention for sleep issues may reduce depression risk in this group.