ArticleFrontiers in medicine2026
Combined lactate, base excess, and MEWS score as predictors of ICU transfer from the emergency department: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Accurate risk stratification of emergency department (ED) patients transferred to the intensive care unit (ICU) is essential for improving outcomes. The traditional Modified Early Warning Score (MEWS) alone has limited utility in predicting mortality risk. Combining MEWS with arterial blood gas parameters-lactate (Lac) and base excess (BE)-may enhance predictive performance. Methods: A retrospective cohort study was conducted involving 262 ED patients admitted to the ICU, who were divided into a non-survivor group ( Results: Multivariate Cox regression analysis showed that both Lac were independent risk factors for 28-day mortality (both Conclusion: Lac and BE are independent predictors of 28-day mortality in ED patients admitted to the ICU. BE adds significantly more predictive value to MEWS than Lac. The Lac + BE + MEWS combined model demonstrates the strongest stability and optimal risk-stratification performance, particularly for patients with MEWS scores of 5-8.
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