Evidence map›Paper›PMID 41640332›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Supramolecular Assemblies of Self-Immolative Janus Dendrimers With Rapid Photodegradation Response.

Chuanfeng Li, Jiabin Luan, Daniela A Wilson, Elizabeth R Gillies

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chuanfeng LiDepartment of Chemistry, The University of Western Ontario, London, Ontario, Canada.
Jiabin LuanInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0001-6484-4083
Daniela A WilsonInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-8796-2274
Elizabeth R GilliesDepartment of Chemistry, The University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-3983-2248

Funding

Canada Excellence Research Chairs, Government of Canada CRC-2020-00101H2020 European Research Council 101044434H2020 European Research Council CoGH2020 European Research Council ERC-Natural Sciences and Engineering Research Council of Canada RGPIN-2021-03950Radboud-Western Collaboration Fund
6 · The paper itself

Abstract

Advanced supramolecular assemblies with predefined lifetimes and rapid responses to stimuli are in high demand for applications such as biomedical delivery systems. However, such assemblies are rarely able to respond rapidly and completely to stimuli, with predictable changes in morphology. Here, we introduce monodisperse self-immolative Janus dendrimers (SIJDs) composed of hydrophilic oligo(ethylene glycol)-functionalized phenolic acid dendrons and hydrophobic monodisperse oligo(ethyl glyoxylate) chains having light-responsive end-groups. These SIJDs self-assemble into spherical nanoparticles in aqueous media. Upon ultraviolet (UV) light irradiation, the hydrophobic oligo(ethyl glyoxylate) units exhibit rapid end-to-end self-immolation within minutes. The depolymerization at the molecular level leads to a degradation pathway from spherical to crescent-shaped nanoparticles, which can be used for the rapid release of encapsulated molecules of interest.

Indexed as

degradationJanus dendrimerself‐assemblyself‐immolativesupramolecular chemistry

Identifiers

PMID41640332
PMCPMC13040118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.