Evidence map›Paper›PMID 41640298›Full record

ArticleJournal of the American Chemical Society2026

Monooxygenase Activity of Indoleamine 2,3-Dioxygenase.

Ali B Lubis, Anna J Bailey, Marko Hanževački, Christopher Williams, Mehul Jesani, Lola González-Sánchez, Christopher J Arthur, Hannah C Wilson, Andrea E Gallio, Peter C E Moody and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Ali B LubisSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0009-0008-9136-434X
Anna J BaileySchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.
Marko HanževačkiCentre for Computational Chemistry, School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.ORCID 0000-0002-0834-871X
Christopher WilliamsSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0001-5806-9842
Mehul JesaniSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.
Lola González-SánchezInstitute for Structural and Chemical Biology, Department Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
Christopher J ArthurSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.
Hannah C WilsonSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.
Andrea E GallioSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0003-3094-681X
Peter C E MoodyInstitute for Structural and Chemical Biology, Department Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.
Matthew P CrumpSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0002-7868-5818
Adrian J MulhollandCentre for Computational Chemistry, School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.ORCID 0000-0003-1015-4567
Allen M OrvilleResearch Complex at Harwell, Harwell Science and Innovation Campus Didcot, Didcot, Oxfordshire OX11 ODE, U.K.ORCID 0000-0002-7803-1777
Jonathan ClaydenSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0001-5080-9535
Emma L RavenSchool of Chemistry, University of Bristol Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0002-1643-8694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indoleamine 2,3-dioxygenase (IDO) is a heme-dependent enzyme that catalyzes the first, rate-limiting step of the kynurenine pathway─the oxidation of l-tryptophan to

Indexed as

Indoleamine-Pyrrole 2,3,-DioxygenaseHumansKynurenineTryptophanIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineTryptophan

Identifiers

PMID41640298
PMCPMC12921851

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.