Evidence map›Paper›PMID 41640244›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.

Wei-Tang Liu, Zhi-Bin Hu, Ling Hu, Yu-Bing Wang, Qiong Zhang, Ning-Ning Song, Xi-Yue Liu, Jia-Yin Chen, Hong-Wen Zhu, Bing-Yao Zhou and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nutrients · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Wei-Tang LiuShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0006-6444-3726
Zhi-Bin HuLaboratory Animal Center, Fudan University, Shanghai, China.
Ling HuLaboratory Animal Center, Fudan University, Shanghai, China.
Yu-Bing WangShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China.
Qiong ZhangLaboratory Animal Center, Fudan University, Shanghai, China.
Ning-Ning SongLaboratory Animal Center, Fudan University, Shanghai, China.
Xi-Yue LiuState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Jia-Yin ChenLaboratory Animal Center, Fudan University, Shanghai, China.
Hong-Wen ZhuPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, China.
Bing-Yao ZhouState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Yun-Chao TaoState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Li ZhaoState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Ze-Xuan LiLaboratory Animal Center, Fudan University, Shanghai, China.
Yi-Wei LiLaboratory Animal Center, Fudan University, Shanghai, China.
Jia-Qi ChenState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Si-Xin TuLaboratory Animal Center, Fudan University, Shanghai, China.
Cong-Cong QiLaboratory Animal Center, Fudan University, Shanghai, China.
Sai-Dan DingLaboratory Animal Center, Fudan University, Shanghai, China.
Gang PengState Key Laboratory of Brain Function and Disorders and MOE Frontiers Center For Brain Science, Institute of Brain Science, Fudan University, Shanghai, China.
Lin XuKey Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Science, Kunming, China.
Yu-Qiang DingShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-1202-4635

Funding

Collaborative Innovation Program of the Shanghai Municipal Health Commission 2020CXJQ01National Natural Science Foundation of China 32271072Natural Science Foundation of Shanghai 22ZR1466300Natural Science Foundation of Shanghai 23ZR1413500Shanghai Municipal Science and Technology Major Project 2018SHZDZX01STI 2030-Major Projects 2022ZD0204900Zhangjiang Laboratory
6 · The paper itself

Abstract

Major Innate Disordered Notch2-Associated Receptor 1 (MINAR1) is known to suppress angiogenesis and breast cancer cell growth and is associated with neurological disorders such as epilepsy. However, its neurobiological function remains unclear. Herein, we reveal the specific expression of MINAR1 in somatostatin (SST)- and parvalbumin (PV)-positive interneurons in the mouse forebrain. To explore its functional significance, MINAR1 conditional knockout (CKO) mice were generated from Nestin-Cre mice. During postnatal growth, gross brain morphology and cytoarchitecture were comparable between MINAR1 CKO mice and littermate controls; adult CKO mice exhibited increased vulnerability to pentylenetetrazole (PTZ)-induced seizures, and this phenotype was also present in SST-Cre-mediated CKO mice. Mechanistically, MINAR1 deficiency selectively impaired SST

Indexed as

Cyclic AMPGTP-Binding Protein alpha Subunits, GsNeuronsSeizuresSomatostatinAnimalsDisease Models, AnimalInterneuronsMiceMice, KnockoutSignal TransductionCyclic AMPGTP-Binding Protein alpha Subunits, GsSomatostatinexcitatory and inhibitory balanceGαsinhibitory neuronMINAR1seizure susceptibility

Identifiers

PMID41640244
PMCPMC13073241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.