Evidence map›Paper›PMID 41640162›Full record

ReviewProblemy endokrinologii2026

[Optimal serum 25(OH)D levels in relation to musculoskeletal, metabolic, neurological, autoimmune and infectious diseases].

E A Troshina, E A Pigarova, T L Karonova, F Kh Dzgoeva, V E Radzinskiy, I I Baranov, O M Lesnyak, Yu E Dobrokhotova, I V Kuznetsova, N V Zarochentseva and 5 more

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Problemy endokrinologii, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

E A TroshinaFederal State Budgetary Institution «I.I. Dedov National Medical Research Center of Endocrinology» of the Russian Ministry of Health.
E A PigarovaFederal State Budgetary Institution «I.I. Dedov National Medical Research Center of Endocrinology» of the Russian Ministry of Health.
T L KaronovaFederal State Budgetary Institution «V.A. Almazov National Medical Research Center of Endocrinology» of the Russian Ministry of Health.
F Kh DzgoevaFederal State Budgetary Institution «I.I. Dedov National Medical Research Center of Endocrinology» of the Russian Ministry of Health.
V E RadzinskiyPatrice Lumumba Peoples' Friendship University of Russia.
I I BaranovFederal State Budgetary Institution «Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology» of the Russian Ministry of Health.
O M LesnyakState Budgetary Educational Institution of Higher Professional Education «North-Western State Medical University named after I.I. Mechnikov National Research Medical University of the Russian Ministry of Health.
Yu E DobrokhotovaPirogov Russian National Research Medical University of the Russian Ministry of Health.
I V KuznetsovaInternational Association of Gynecologists, Endocrinologists, and Therapists (IAGET).
N V ZarochentsevaMoscow Regional Research and Clinical Institute («MONIKI»).
G R BayramovaFederal State Budgetary Institution «Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology» of the Russian Ministry of Health.
O A RadaevaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University.
E V EkushevaAcademy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia.
L A SuplotovaTyumen State Medical University of the Russian Ministry of Health.
E V MatushevskayaAcademy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia.

Funding

Akrikhin
6 · The paper itself

Abstract

This article presents an overview of current research on determining target blood levels of vitamin D. It examines the biochemical and metabolic properties of vitamin D, as well as the challenges of standardizing 25(OH)D measurements and the variability of threshold values across populations. It discusses ambiguities in scientific data and the need to consider individual factors when interpreting vitamin D levels. This review is unique in its comprehensive approach to analyzing the effects of vitamin D not only on bone health but also on immune and metabolic functions, which broadens ever evolving understanding of the clinical significance of vitamin D. This work emphasizes the importance of personalized recommendations for vitamin D dosing and prescription based on current clinical data and scientific standards. Performed analysis highlights the need for personalized vitamin D supplementation to reach and maintain blood levels between 30 and 60 ng/mL, noting that higher levels might be necessary for people with genetic or acquired resistance. These insights substantiate the development of evidence-based, personalized clinical strategies for the prevention and treatment of vitamin D deficiency-related disorders. The synthesized data offer significant implications for advancing research and clinical practice in endocrinology, obstetrics, dermatology, neurology and immunology.

Indexed as

Vitamin DVitamin D DeficiencyAutoimmune DiseasesCommunicable DiseasesDietary SupplementsHumansMetabolic DiseasesMusculoskeletal DiseasesNervous System DiseasesPrecision Medicine25-hydroxyvitamin DVitamin D

Identifiers

PMID41640162
PMCPMC12954428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.