Evidence map›Paper›PMID 41640111›Full record

ArticlemAbs2026

Dual agonism and selective T-cell depletion activity of a PD-1-directed antibody for treating autoimmune diseases.

Wenbo Jiang, Lingyun Li, Weili Xue, Xuzhi He, Xuebin Chu, Lei Song, Xue Li, Ranran Zhao, Xinghang Yuan, Xiaoliang Jin and 10 more

Abstract read
In one paragraph

Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Understanding the Therapeutic Potential of PD-1 Agonism in Inflammatory and Autoimmune Disorders.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wenbo JiangInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Lingyun LiInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Weili XueInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Xuzhi HeInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Xuebin ChuInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Lei SongInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Xue LiInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Ranran ZhaoInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Xinghang YuanInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Xiaoliang JinInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Lishi FanInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Tian SunInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Aisi ZhuInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Ling ZhouInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Fei GuInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Qian XuInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Guangli MaInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Siqin WangInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
Lei JinInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.
John L XuInstitute of Research and Development, Changchun GeneScience Pharmaceutical Co., Ltd., Changchun, Jilin, China.ORCID 0009-0002-7173-4901

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise inhibition of autoreactivity without concomitant induction of general immunosuppression is an overarching goal that remains elusive for the treatment of autoimmune diseases. PD-1 is preferentially expressed on activated T cells that drive autoimmunity. These PD-1

Indexed as

Antibodies, MonoclonalAutoimmune DiseasesProgrammed Cell Death 1 ReceptorT-LymphocytesAnimalsFemaleHumansMiceProtein Tyrosine Phosphatase, Non-Receptor Type 11Signal TransductionAntibodies, MonoclonalPDCD1 protein, humanProgrammed Cell Death 1 ReceptorProtein Tyrosine Phosphatase, Non-Receptor Type 11agonist antibodyautoimmunityimmune balanceimmune tolerancePD-1peripheral Th cellsSHP2 recruitment

Identifiers

PMID41640111
PMCPMC12885395

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.