ArticleJournal of nanobiotechnology2026
High-entropy layered double hydroxide nanosheets reprogram tumor homeostasis for ultrasound-enhanced pyroptosis-mediated immunotherapy.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Synergistic disruption of redox and energy homeostasis via high-entropy layered double hydroxide nanozymes for enhanced tumor therapy.iScience · 2026Article
- Ultrasound-activated nanoregulator enables CuJournal of nanobiotechnology · 2026Article
- Advancements in nanomedicines for cancer therapy: targeting molecular signaling pathways, activating immune cells, and using photothermal immunomodulation.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
10 authors.
Funding
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Abstract
Developing redox nanozymes able to disrupt cellular homeostasis and promoting immunotherapy offers great potentials to develop highly efficient cancer therapy, but remains challenging. Herein, we initially proposed a high entropy-based layered double hydroxide (LDH) nanosheets (denoted as HE-NS) regulation strategy to achieve high yields of reactive oxygen species (ROS), breaking relatively vulnerable homeostasis, remodeling the tumor microenvironment (TME), further trigger cell pyroptosis. Specifically, compared with low entropy and medium entropy LDH, this unique HE-NS exhibits better multienzyme catalytic activity, which can be further enhanced under ultrasound (US) irradiation. Density functional theory (DFT) calculations confirm that this superior performance can be attributed to the multi-element environment in HE-NS, which optimally modulates the electronic structure of the Fe active site. This modulation yields an intermediate hydrogen peroxide (H
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