Evidence map›Paper›PMID 41639801›Full record

ArticleBMC psychiatry2026

Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study.

Maria Vestergaard, Rikke Faergemann Hansen, Per Hove Thomsen, Andreas Hoiberg Bentsen, Anne Cathrine Falch-Joergensen

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Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Maria VestergaardSignum Life Science, Real World Evidence, Lersø Parkallé 101, Copenhagen K, 2100 , Denmark. mve@signumlifescience.com.
Rikke Faergemann HansenSignum Life Science, Real World Evidence, Lersø Parkallé 101, Copenhagen K, 2100 , Denmark.
Per Hove ThomsenDepartment of Child & Adolescent Psychiatry, Aarhus University Hospital, Aarhus, Denmark.
Andreas Hoiberg BentsenSignum Life Science, Real World Evidence, Lersø Parkallé 101, Copenhagen K, 2100 , Denmark.
Anne Cathrine Falch-JoergensenSignum Life Science, Real World Evidence, Lersø Parkallé 101, Copenhagen K, 2100 , Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo examine the prevalence of comorbidities and the use of psychiatric comedication among individuals in medical treatment for attention deficit hyperactivity disorder (ADHD), in comparison to a matched control group from the general population.

methodsThis nationwide case-control study included 1,082,378 Danish individuals aged 7-64 of whom 98,398 had at least one prescription of ADHD medication during 2023. Data was collected over an observation period spanning from 2013 to 2023. Cases were matched to controls (1:10) from the general population on birth year and sex. Data were obtained and accessed through The Danish Health Data Authority. Associations were estimated using conditional logistic regression models.

resultsSomatic and particularly psychiatric comorbidities were more common among individuals in ADHD treatment across all age groups. Among those in ADHD treatment 46.7% had at least one comorbidity compared to 23.3% in the control group. The use of psychiatric comedications (besides ADHD medication) was likewise more common among individuals in ADHD treatment (32.7%) compared to the controls (7.2%). The association estimates from conditional logistic regression revealed a higher likelihood of somatic and psychiatric comorbidities among those in ADHD treatment in all age groups. Females in ADHD treatment had 4.48-4.50 times higher odds of comorbidities compared to females not in ADHD treatment (OR

conclusionThis study reveals that both prevalence of somatic and psychiatric comorbidities and the use of psychiatric comedication are significantly higher among individuals in ADHD treatment. The highest occurrence is seemingly among females aged 7-17 year and 18-29 years. The coexistence of ADHD with other somatic and psychiatric conditions can constitute a more complex disease burden, necessitating enhanced disease management strategies to reduce complications and enhance quality of life. Longitudinal studies are needed to confirm the temporal association of these results.

Indexed as

Attention Deficit Disorder with HyperactivityMental DisordersAdolescentAdultCase-Control StudiesChildComorbidityDenmarkFemaleHumansMaleMiddle AgedPrevalenceYoung AdultADHD medicationsAttention deficit hyperactivity disorder (ADHD)ComedicationPolypharmacyPsychiatric comorbiditiesPsychiatric medicationsSomatic comorbidities

Identifiers

PMID41639801
PMCPMC12922213

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