Evidence map›Paper›PMID 41639776›Full record

SynthesisBMC infectious diseases2026

New onset of severe and long-term hepatobiliary diseases post-COVID-19 infection: a systematic review.

Ali Aboulwafa, Ahamed Lebbe, Aya Khalil, Nuran Bayraktar, Beshr Mushannen, Sama Ayoub, Shaunak Sarker, Marwan Nour Abdalla, Sa'ad Laws, Ibrahim Mohammed and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ali Aboulwafa *Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Ahamed Lebbe *Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Aya KhalilWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Nuran BayraktarWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Beshr MushannenWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Sama AyoubWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Shaunak SarkerWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Marwan Nour AbdallaWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Sa'ad LawsWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar.
Ibrahim MohammedAlbany Medical College, Albany, NY, USA.
Lina YaganDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Malik MushannenNew York-Presbyterian Brooklyn Methodist Hospital, New York, NY, USA.
Dalia ZakariaWeill Cornell Medicine-Qatar, Qatar Foundation, Education City, P.O. Box 24144, Al Luqta St., Ar-Rayyan,Doha, Qatar. dez2003@qatar-med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic has resulted in a surge of reports linking the virus to various systemic complications, including hepatobiliary disorders. Understanding the spectrum and severity of hepatobiliary diseases following COVID-19 infection is crucial for comprehensive patient management and long-term health outcomes.

methodsA systematic review was conducted to identify studies reporting on hepatobiliary manifestations post-COVID-19 infection. PubMed, Medline, Embase, Scopus, Web of Science, Science Direct and Cochrane Library databases were searched in October 2023, with set inclusion and exclusion criteria in place to select papers documenting new onset hepatobiliary diseases following COVID-19 infection.

resultsA total of 23 studies met the inclusion criteria, covering a diverse range of hepatobiliary conditions such as acute hepatitis, cholestasis, autoimmune liver diseases, and gallbladder pathology.

conclusionThis systematic review underscores the emerging evidence of severe and long-term hepatobiliary diseases following COVID-19 infection. Healthcare providers should maintain a high index of suspicion for hepatobiliary complications in patients recovering from COVID-19, emphasizing the need for prolonged monitoring and specialized management strategies to mitigate long-term morbidity and mortality."

Indexed as

Biliary Tract DiseasesCOVID-19Liver DiseasesHumansPost-Acute COVID-19 SyndromeSARS-CoV-2“biliary disease”“cholangiopathy”COVID-19“hepatic injury”“hepatobiliary disease”“liver injury”“long-COVID”“post-COVID sequelae”SARS-CoV-2

Identifiers

PMID41639776
PMCPMC12870127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.