Evidence map›Paper›PMID 41639535›Full record

ArticleNeurotoxicity research2026

IGF2BP1 Aggravates NLRP3 Inflammasome Activation and Pro-Inflammatory Phenotype in Microglia-like Cells by Promoting TRIM45 Expression.

Pei Wang, Yanling Huang, Qian Ma, Yueqin Zhou, Xuefei Wang, Liu Yang, Tao Meng

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pei Wang *Department of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China.
Yanling Huang *Department of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China.
Qian Ma *Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Yueqin ZhouDepartment of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China.
Xuefei WangDepartment of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China.
Liu YangDepartment of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China.
Tao MengDepartment of Neurology, Chongqing University Central Hospital, Chongqing Key Laboratory of Emergency Medicine, NO.1 Jiankang Road, Yuzhong District, Chongqing, 400014, China. mengtaopro@163.com.

Funding

Chongqing Key Laboratory of Emergency Medicine 2023KFKT10
6 · The paper itself

Abstract

Cerebral ischemia-reperfusion (I/R) injury is the main cause of early complications and adverse outcomes after treatment such as myocardial infarction and acute ischemic stroke. In this study, we aimed to explore the functions of insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) and tripartite motif-containing 45 (TRIM45) in neuron injury after cerebral I/R injury. HMC3 cells were exposed to oxygen-glucose deprivation and reoxygenation (OGD/R) to mimic cerebral I/R injury in vitro. Western blot and qRT-PCR were conducted for gene expression. NLR family pyrin domain containing 3 (NLRP3) inflammasome activity was analyzed by western blot. ELISA kits were utilized to determine the concentrations of inflammatory cytokines. Flow cytometry was used to analyze iNOS

Indexed as

InflammasomesMicrogliaNLR Family, Pyrin Domain-Containing 3 ProteinRNA-Binding ProteinsTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsCell LineHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLNeuronsPhenotypeReperfusion InjuryIGF2BP1 protein, humanInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinRNA-Binding ProteinsTripartite Motif ProteinsUbiquitin-Protein LigasesHMC3 cellsIGF2BP1I/R injuryNeuronOGD/RTRIM45

Identifiers

PMID41639535

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.