ArticleNature2026
Atlas-guided discovery of transcription factors for T cell programming.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A Gene-Program Architecture of Mouse T cells.bioRxiv : the preprint server for biology · 2026Article
- Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.Nature immunology · 2026Article
- Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nature immunology · 2026Article
- Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8Research square · 2026Article
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Transcription factor collaboration enables precise T cell state engineering.bioRxiv : the preprint server for biology · 2026Article
- Optimal transport fate mapping resolves T cell differentiation dynamics across tissues.bioRxiv : the preprint server for biology · 2026Article
- Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential.bioRxiv : the preprint server for biology · 2026Article
- T cell decision-making decodes the dynamic antigenic landscape.Frontiers in immunology · 2026Review
Corrections and comments
- Erratum issued
- Update of
Authors and funding
50 authors.
H Kay Chung *NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA. hkchung@unc.edu.ORCID 0000-0002-7028-2432
Cong Liu *Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Anamika BattuLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-5075-9101
Alexander N JamborBioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1264-4084
Brandon M PrattLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-1509-7509
Fucong XieLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brian P RiesenbergLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Eduardo CasillasNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Ming SunNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Elisa LandoniLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yanpei LiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Qidang YeLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Daniel JooLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jarred GreenLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zaid SyedLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nolan J BrownLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Matthew SmithLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shixin MaNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Shirong TanNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Brent ChickMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-0193-1654
Victoria TrippleNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Z Audrey WangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jun WangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Bryan McdonaldNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Peixiang HeAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Qiyuan YangNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-6204-9094
Timothy ChenNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0009-0002-7003-2721
Siva Karthik VaranasiNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Michael A LaPortaNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0009-0001-0461-5614
Thomas H MannNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-3821-1466
Dan ChenNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Filipe HoffmannNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0009-0009-5042-5334
Josephine HoMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Jennifer ModliszewskiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
April WilliamsRazavi Newman Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-9281-8528
Yusha LiuLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Zhen WangHalıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Jieyuan LiuHalıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Yiming GaoDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.ORCID 0009-0003-7436-9070
Zhiting HuHalıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Ukrae H ChoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Longwei LiuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4229-9066
Yingxiao WangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Diana C HargreavesMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-3724-3826
Gianpietro DottiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Barbara SavoldoLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jessica E ThaxtonLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Justin MilnerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-0752-2130
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA. sue.kaech@alleninstitute.org.ORCID 0000-0003-1674-1420
Wei WangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA. wei-wang@ucsd.edu.ORCID 0000-0003-4377-5060
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MRegulation of memory CD8 T cell developmentR01AI066232 · NIAID · YALE UNIVERSITY · PI Diana Clare Hargreaves · 2005 to 2026
$5.7MIntegrated analysis of genetic variation and epigenomic dataR01HG009626 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2017 to 2025
$4.5MThe role of BAF related complexes in regulatory T cell development and functionR01AI151123 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HARGREAVES, DIANA CLARE, ZHENG, YE · 2020 to 2024
$4.0MSystems-level identification of key regulators deciding immune cell stateR01AI150282 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2020 to 2024
$3.5MUnderstanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunityR01CA240909 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2024
$3.0MAcoustothermogenetics for Cell EngineeringR35GM140929 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, YINGXIAO · 2021 to 2025
$2.9MCellular Mechanisms of Viral ControlR01AI123864 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CAULEY, LINDA S, KAECH, SUSAN M · 2016 to 2020
$2.0MTargeting Chronic ER Stress in T Cells to Improve Cancer ImmunotherapyR01CA244361 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THAXTON, JESSICA E · 2020 to 2024
$1.9MUltrasound-controlled remote activation of CAR T cells for localized tumor immunotherapyR01EB029122 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, YINGXIAO · 2020 to 2023
$1.7MExpoitation of ER Stress Induced Immune Dysfunction to Improve ImmunotherapyR01CA248359 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THAXTON, JESSICA E · 2020 to 2024
$1.7MEpigenetic regulation of T cell differentiation during infectionR01AI177864 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI John Justin Milner · 2024 to 2026
$1.7MNCI NIH HHS P30 CA016086NCI NIH HHS R01 CA240909NCI NIH HHS R01 CA244361NCI NIH HHS R01 CA248359NHGRI NIH HHS R01 HG009626NIAID NIH HHS R01 AI066232NIAID NIH HHS R01 AI123864NIAID NIH HHS R01 AI150282NIAID NIH HHS R01 AI151123NIAID NIH HHS R01 AI177864NIAID NIH HHS R21 AI151986NIBIB NIH HHS K01 EB034321NIBIB NIH HHS K01 EB035649NIBIB NIH HHS R01 EB029122NIGMS NIH HHS R35 GM140929
Abstract
CD8
Indexed as
CD8-Positive T-LymphocytesCell DifferentiationTranscription FactorsAnimalsAtlases as TopicEpigenesis, GeneticFemaleHumansImmunologic MemoryMaleMemory T CellsMiceMice, Inbred C57BLNeoplasmsPositive Regulatory Domain I-Binding Factor 1Single-Cell AnalysisPositive Regulatory Domain I-Binding Factor 1Transcription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.