Evidence map›Paper›PMID 41639461›Full record

ArticleNature2026

Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness.

Katharine Cecchini, Mina Zamani, Nandagopal Ajaykumar, Joel Vega-Badillo, Ayca Bagci, Shannon Bailey, Phillip D Zamore, Ildar Gainetdinov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The pachytene-specific lncRNANon-coding RNA research · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharine CecchiniRNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Mina ZamaniDepartment of Biology, New York University, New York, NY, USA.
Nandagopal AjaykumarDepartment of Biology, New York University, New York, NY, USA.
Joel Vega-BadilloRNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-7110-6377
Ayca BagciRNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Shannon BaileyRNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Phillip D ZamoreRNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. Phillip.Zamore@umassmed.edu.ORCID 0000-0002-4505-9618
Ildar GainetdinovDepartment of Biology, New York University, New York, NY, USA. Ildar.Gainetdinov@nyu.edu.ORCID 0000-0003-1719-043X

Funding

Understanding the Evolution, Biology, and Molecular Mechanism of Argonaute ProteinsR35GM136275 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PHILLIP D ZAMORE · 2020 to 2026
$3.3M
Transmission Electron Microscope for Core EM FacilityS10RR027897 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2009 to 2009
$500k
NCRR NIH HHS S10 RR027897NIGMS NIH HHS R35 GM136275
6 · The paper itself

Abstract

Animals use 18-33-nucleotide PIWI-interacting RNAs (piRNAs) to silence transposons in germ cells

Indexed as

Genetic FitnessPachytene StageRNA CleavageRNA, MessengerRNA, Small InterferingSpermatozoaAnimalsFemaleMaleMicePiwi-Interacting RNAProtein BiosynthesisTestisPiwi-Interacting RNARNA, MessengerRNA, Small Interfering

Identifiers

PMID41639461
PMCPMC13061629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.