ArticleNature2026
ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression.
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In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Supratentorial ependymoma: a comprehensive review of molecular classification, management strategies, and clinical outcomes (Part II of pediatric ependymomas across compartments).Journal of neuro-oncology · 2026Review
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Metabolic vulnerability in fusion-driven ependymoma.Nature reviews. Cancer · 2026Article
- Sustainable Community-Wide Model to Enhance Cancer Data Usage and Utility.JCO clinical cancer informaticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors.
Siva Kumar NatarajanLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Joanna LumLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
James Haggerty SkeansLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Minal NenwaniLaboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA.
Sanjana EyunniMolecular and Cellular Pathology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.
Mateus MotaLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jill M BaylissLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7995-5584
Akash DeogharkarLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Erin Taya HamanishiLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Matthew PunLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Stefan R SwehaLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Simon HoffmanLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0000-1385-6316
Eleanor YoungMichigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5393-530X
Qiuyang ZhangRogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Rijul MehtaLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Olamide AnimasahunLaboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4032-3619
Pranav NarayananLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sushanth SunilLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Abhijit ParoliaMichigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8556-7481
Pooja PanwalkarLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Robert DohertyDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Madison ClausenDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0007-1460-5464
Derek DangLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Debra HawesDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA.
Fusheng YangDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8040-6312
Mariarita SantiAnatomic Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alexander R JudkinsDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA.
Yelena WilsonDepartment of Pathology, Akron Children's Hospital, Akron, OH, USA.
Thomas VigilDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Andrea FransonDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5361-7683
Richard M MortensenDepartments of Molecular and Integrative Physiology, Internal Medicine, and Pharmacology, University of Michigan, Ann Arbor, MI, USA.
Tatsuya OzawaHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Andrea GriesingerDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric C HollandHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3792-7120
Nicholas K ForemanDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kulandaimanuvel Antony MichealrajDepartment of Neurosurgery, University of Pittsburgh School of Medicine and Cancer 97 Biology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3967-0816
Sameer AgnihotriDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael TaylorDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7009-3466
Richard J GilbertsonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7539-9472
Carl KoschmannDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Arul M ChinnaiyanMichigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9282-3415
Costas A LyssiotisRogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9309-6141
Deepak NagrathLaboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8999-2282
Sriram VennetiLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. svenneti@med.umich.edu.
Funding
The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancerR35CA253119 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric C. Holland · 2021 to 2026
$6.5MExploring Precision Oncology: From Gene Fusions to lncRNAsR35CA231996 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 2018 to 2024
$6.4MTargeting integrated metabolic and epigenetic pathways in childhood ependymomasR01CA261926 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Deepak Nagrath, Benita Tamrazi · 2022 to 2026
$3.0MUnravelling metabolic dependencies in H3K27M mutant DIPGR01NS110572 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2019 to 2026
$2.7MTargeting EGFR/FOXG1-mediated resistance to ONC201 in H3K27M-mutant diffuse midline gliomaR01NS124607 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carl J Koschmann · 2022 to 2026
$2.2MThe role of ATRX mutation in the epigenetic dysregulation of cell cycle in pediatric high-grade gliomaR01NS119231 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOSCHMANN, CARL J · 2021 to 2025
$1.9MTargeting metabolic dependencies in ZFTA-RELA fusion childhood ependymomasR01NS127799 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2023 to 2026
$1.8MNCI NIH HHS R01 CA261926NCI NIH HHS R35 CA231996NCI NIH HHS R35 CA253119NINDS NIH HHS R01 NS110572NINDS NIH HHS R01 NS119231NINDS NIH HHS R01 NS124607NINDS NIH HHS R01 NS127799
Abstract
ZFTA-RELA
Indexed as
Brain NeoplasmsEpendymomaEpigenesis, GeneticGene Expression Regulation, NeoplasticSuccinatesTranscription Factor RelAAnimalsCarboxy-LyasesCell Line, TumorFemaleGlutamineHistonesHumansMaleMiceUp-RegulationCarboxy-LyasesGlutaminehistone H3 trimethyl Lys4Histonesitaconic acidRELA protein, humanSuccinatesTranscription Factor RelA
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.