Evidence map›Paper›PMID 41639454›Full record

ArticleNature2026

PtdIns(3,5)P

Jay Xiaojun Tan, Bo Lv, Jie Li, Tuo Li, Fenghe Du, Xiang Chen, Xuewu Zhang, Xiao-Chen Bai, Zhijian J Chen

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. New frontiers in pathogen immunity.Nature immunology · 2026
    Article
  3. Review
  4. Article
  5. Autoinflammatory syndromes of STING and TREX1 dysfunction.The Journal of clinical investigation · 2026
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jay Xiaojun Tan *Aging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Jay.Tan@Pitt.edu.ORCID 0000-0003-3300-2240
Bo Lv *Aging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-3448-8986
Jie LiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1059-280X
Tuo LiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6268-7520
Fenghe DuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiang ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xuewu ZhangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-3634-6711
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4234-5686
Zhijian J ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Zhijian.Chen@UTSouthwestern.edu.ORCID 0000-0002-8475-8251

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JAY D. HORTON · 2022 to 2026
$7.4M
Novel regulatory mechanisms and agonists of STINGR01CA273595 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, CHUO CHEN · 2023 to 2026
$2.7M
Biochemical Dissection of the RIG-I Antiviral PathwayR01AI093967 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ZHIJIAN J · 2011 to 2015
$2.0M
Lysosomal quality control through lipid remodelingR35GM150506 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Xiaojun Tan · 2023 to 2026
$1.8M
Novel endogenous and engineered activators of STING: from mechanisms to cancer therapyR01CA299257 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Xiaochen Bai, Zhijian J Chen · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA273595NCI NIH HHS R01 CA299257NIAID NIH HHS R01 AI093967NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R35 GM150506
6 · The paper itself

Abstract

Exposure to cytosolic DNA triggers innate immune responses through cyclic GMP-AMP (cGAMP) synthase (cGAS)

Indexed as

Immunity, InnateMembrane ProteinsPhosphatidylinositol PhosphatesSignal TransductionAnimalsCryoelectron MicroscopyEndoplasmic ReticulumGolgi ApparatusHEK293 CellsHumansLigandsMiceNucleotides, CyclicNucleotidyltransferasesPhosphatidylinositol 3-KinasesProtein Serine-Threonine Kinasescyclic guanosine monophosphate-adenosine monophosphateLigandsMembrane ProteinsNucleotides, CyclicNucleotidyltransferasesphosphatidylinositol 3,5-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPIKFYVE protein, humanProtein Serine-Threonine KinasesSTING1 protein, humanSTING ProteinTBK1 protein, human

Identifiers

PMID41639454
PMCPMC13222494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.